Host translation inhibitor nsp1

QHD43415_1

MTR: 0.88 (Intolerant)

RVIS: -0.17 (Intolerant)

Non-structural protein 2 (nsp2)

QHD43415_2

MTR: 0.87 (Intolerant)

RVIS: 0.5 (Tolerant)

Papain-like proteinase (PLpro)

QHD43415_3

MTR: 0.83 (Intolerant)

RVIS: 0.05 (Tolerant)

Non-structural protein 4 (nsp4)

QHD43415_4

MTR: 0.75 (Intolerant)

RVIS: -1.1 (Intolerant)

Main proteinase 3CL-PRO

QHD43415_5

MTR: 0.79 (Intolerant)

RVIS: -0.3 (Intolerant)

Non-structural protein 6 (nsp6)

QHD43415_6

MTR: 0.78 (Intolerant)

RVIS: -0.3 (Intolerant)

Non-structural protein 7 (nsp7)

QHD43415_7

MTR: 0.76 (Intolerant)

RVIS: -0.12 (Intolerant)

Non-structural protein 8 (nsp8)

QHD43415_8

MTR: 0.72 (Intolerant)

RVIS: -0.26 (Intolerant)

Non-structural protein 9 (nsp9)

QHD43415_9

MTR: 0.68 (Intolerant)

RVIS: -0.1 (Intolerant)

Replicase Polyprotein 1ab

QHD43415_11

MTR: 0.74 (Intolerant)

RVIS: -1.77 (Intolerant)

Helicase (Hel)

QHD43415_12

MTR: 0.69 (Intolerant)

RVIS: -0.42 (Intolerant)

Guanine-N7 methyltransferase (ExoN) / Proofreading exoribonuclease

QHD43415_13

MTR: 0.72 (Intolerant)

RVIS: -1.03 (Intolerant)

Uridylate-specific endoribonuclease (NendoU)

QHD43415_14

MTR: 0.82 (Intolerant)

RVIS: -0.46 (Intolerant)

Surface glycoprotein (Spike)

QHD43416

MTR: 0.85 (Intolerant)

RVIS: -0.14 (Intolerant)

ORF3a

QHD43417

MTR: 0.95 (Intolerant)

RVIS: 2.78 (Tolerant)

Envelope Small Membrane Protein

QHD43418

MTR: 0.88 (Intolerant)

RVIS: -0.11 (Intolerant)

Membrane Glycoprotein

QHD43419

MTR: 0.77 (Intolerant)

RVIS: -0.19 (Intolerant)

ORF6

QHD43420

MTR: 0.85 (Intolerant)

RVIS: 0.02 (Tolerant)

ORF7a

QHD43421

MTR: 0.89 (Intolerant)

RVIS: 0.44 (Tolerant)

ORF8

QHD43422

MTR: 0.9 (Intolerant)

RVIS: 0.47 (Tolerant)

Nucleocapsid protein

QHD43423

MTR: 0.89 (Intolerant)

RVIS: 4.34 (Tolerant)

ORF10

QHI42199

MTR: 0.96 (Intolerant)

RVIS: 0.26 (Tolerant)

RNA-directed RNA Polymerase/nsp7/nsp8 Complex

RNAP

MTR: 0.73 (Intolerant)

RVIS: -0.97 (Intolerant)

2'-O-methyltransferase (2'-O-MT)/nsp10 Complex

NSP_10_16

MTR: 0.75 (Intolerant)

RVIS: -0.07 (Intolerant)

ORF7b

QIZ15543

MTR: 0.89 (Intolerant)

RVIS: 0.24 (Tolerant)