Non-structural protein 7 (nsp7) (Uniprot: P0DTD1 - GenBank: QHD43415_7)

MTR: 0.76 (Intolerant) / RVIS: -0.12 (Intolerant)

3D Structure launchView Complex

Sequence
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Mutational Tolerance (Missense Tolerance Ratio)

Horizontal lines show gene-specific MTR percentiles 5th, 25th, 50th, and neutrality (MTR = 1.0)

Mutations launchAnalysis launchSaturation Mutagenesis
info_outline

SARS-CoV2 Circulating Variants
Position AA from AA to Chain Frequency (%) Depth (Å) Phi (°) Psi (°) RSA (%) SST MTR Score Consurf Score ΔAtomic Fluctuation (Å) ΔEnergy Deformation (kcal/mol) ΔΔGmCSMstability ΔΔGDynaMutstability ΔΔGDUETstability ΔΔGSDMstability ΔΔGENCoMstability ΔΔSENCoMvib Hydrophobics Positives Negatives Acceptors Donnors Aromatics Sulfurs Neutral ΔHydrogen bond ΔIonic ΔAromatic ΔHydrophobic ΔCarbonyl ΔPolar ΔPi blosum100 blosum30 blosum35 blosum40 blosum45 blosum50 blosum55 blosum60 blosum62 blosum65 blosum70 blosum75 blosum80 blosum85 blosum90 blosum95 pam120 pam180 pam250 pam30 pam300 pam60 pam90 HENS920102 HENS920103 WEIL970102 HENS920101 GRAR740104 PRLA000102 HENS920104 WEIL970101 GIAG010101 RISJ880101 DOSZ010102 DOSZ010103 JOND940101 DOSZ010101 ZHAC000101 MIYS990106 ZHAC000103 LIWA970101 QU_C930103 QU_C930102 QU_C930101 ZHAC000106 ZHAC000104 MIYS850102 MIYS850103 MIYS990107 GODA950101 BRYS930101 RIER950101 KOSJ950110_RSA JOND920103 VOGG950101 KESO980102 OGAK980101 NIEK910102 AZAE970101 AZAE970102 NIEK910101 TUDE900101 CROG050101 MIYS930101 MIYS960101 SIMK990105 SIMK990104 TOBD000102 BETM990101 TOBD000101 KOLA920101 MEHP950102 MEHP950101 PRLA000101 JOHM930101 QUIB020101 ROBB790102 MIRL960101 GEOD900101 KOSJ950100_SST DAYM780302 DAYM780301 LUTR910106 LUTR910107 LUTR910104 LUTR910105 LUTR910102 LUTR910103 THOP960101 LUTR910101 GONG920101 MCLA710101 LUTR910108 LUTR910109 SKOJ970101 SKOJ000101 OVEJ920101 KANM000101 VENM980101 RUSR970103 RUSR970102 RUSR970101 LINK010101 MUET010101 KOLA930101 MCLA720101 ALTS910101 LEVJ860101 BONM030101 BONM030106 MOOG990101 BONM030105 ZHAC000105 KAPO950101 OVEJ920100_RSA FEND850101 NGPC000101 SIMK990103 KESO980101 SKOJ000102 TANS760101 TANS760102 MIYT790101 BLAJ010101 PARB960101 CSEM940101 OVEJ920102 OVEJ920103 BONM030103 PARB960102 MICC010101 BONM030102 KOSJ950100_RSA_SST DOSZ010104 MUET020101 MUET020102 ZHAC000102 SIMK990102 NAOD960101 SIMK990101 MEHP950103 MIYS960102 MIYS960103 BONM030104 KOSJ950115 BASU010101 BENS940104 BENS940102 BENS940103 BENS940101 FITW660101 MOHR870101 A A.1 A.1.1 A.1.3 A.2 A.3 A.4 A.5 A.6 B B.1 B.1.1 B.1.1.1 B.1.1.10 B.1.1.13 B.1.1.14 B.1.1.17 B.1.1.18 B.1.1.2 B.1.1.3 B.1.1.4 B.1.1.5 B.1.1.6 B.1.1.7 B.1.1.8 B.1.1.9 B.1.12 B.1.13 B.1.19 B.1.22 B.1.23 B.1.26 B.1.29 B.1.3 B.1.30 B.1.31 B.1.32 B.1.33 B.1.34 B.1.35 B.1.36 B.1.37 B.1.38 B.1.39 B.1.40 B.1.41 B.1.43 B.1.44 B.1.5 B.1.5.1 B.1.5.2 B.1.5.3 B.1.5.4 B.1.5.5 B.1.5.6 B.1.6 B.1.66 B.1.67 B.1.69 B.1.70 B.1.71 B.1.72 B.1.8 B.10 B.13 B.14 B.15 B.16 B.2 B.2.1 B.2.2 B.2.4 B.2.5 B.2.6 B.2.7 B.3 B.4 B.5 B.6 B.7 B.9 Details
Mutations from SARS info_outline
Position AA from AA to Chain Frequency (%) Depth (Å) Phi (°) Psi (°) RSA (%) SST MTR Score Consurf Score ΔAtomic Fluctuation (Å) ΔEnergy Deformation (kcal/mol) ΔΔGmCSMstability ΔΔGDynaMutstability ΔΔGDUETstability ΔΔGSDMstability ΔΔGENCoMstability ΔΔSENCoMvib Hydrophobics Positives Negatives Acceptors Donnors Aromatics Sulfurs Neutral Hydrogen bond Ionic Aromatic Hydrophobic Carbonyl Polar Pi blosum100 blosum30 blosum35 blosum40 blosum45 blosum50 blosum55 blosum60 blosum62 blosum65 blosum70 blosum75 blosum80 blosum85 blosum90 blosum95 pam120 pam180 pam250 pam30 pam300 pam60 pam90 HENS920102 HENS920103 WEIL970102 HENS920101 GRAR740104 PRLA000102 HENS920104 WEIL970101 GIAG010101 RISJ880101 DOSZ010102 DOSZ010103 JOND940101 DOSZ010101 ZHAC000101 MIYS990106 ZHAC000103 LIWA970101 QU_C930103 QU_C930102 QU_C930101 ZHAC000106 ZHAC000104 MIYS850102 MIYS850103 MIYS990107 GODA950101 BRYS930101 RIER950101 KOSJ950110_RSA JOND920103 VOGG950101 KESO980102 OGAK980101 NIEK910102 AZAE970101 AZAE970102 NIEK910101 TUDE900101 CROG050101 MIYS930101 MIYS960101 SIMK990105 SIMK990104 TOBD000102 BETM990101 TOBD000101 KOLA920101 MEHP950102 MEHP950101 PRLA000101 JOHM930101 QUIB020101 ROBB790102 MIRL960101 GEOD900101 KOSJ950100_SST DAYM780302 DAYM780301 LUTR910106 LUTR910107 LUTR910104 LUTR910105 LUTR910102 LUTR910103 THOP960101 LUTR910101 GONG920101 MCLA710101 LUTR910108 LUTR910109 SKOJ970101 SKOJ000101 OVEJ920101 KANM000101 VENM980101 RUSR970103 RUSR970102 RUSR970101 LINK010101 MUET010101 KOLA930101 MCLA720101 ALTS910101 LEVJ860101 BONM030101 BONM030106 MOOG990101 BONM030105 ZHAC000105 KAPO950101 OVEJ920100_RSA FEND850101 NGPC000101 SIMK990103 KESO980101 SKOJ000102 TANS760101 TANS760102 MIYT790101 BLAJ010101 PARB960101 CSEM940101 OVEJ920102 OVEJ920103 BONM030103 PARB960102 MICC010101 BONM030102 KOSJ950100_RSA_SST DOSZ010104 MUET020101 MUET020102 ZHAC000102 SIMK990102 NAOD960101 SIMK990101 MEHP950103 MIYS960102 MIYS960103 BONM030104 KOSJ950115 BASU010101 BENS940104 BENS940102 BENS940103 BENS940101 FITW660101 MOHR870101 A A.1 A.1.1 A.1.3 A.2 A.3 A.4 A.5 A.6 B B.1 B.1.1 B.1.1.1 B.1.1.10 B.1.1.13 B.1.1.14 B.1.1.17 B.1.1.18 B.1.1.2 B.1.1.3 B.1.1.4 B.1.1.5 B.1.1.6 B.1.1.7 B.1.1.8 B.1.1.9 B.1.12 B.1.13 B.1.19 B.1.22 B.1.23 B.1.26 B.1.29 B.1.3 B.1.30 B.1.31 B.1.32 B.1.33 B.1.34 B.1.35 B.1.36 B.1.37 B.1.38 B.1.39 B.1.40 B.1.41 B.1.43 B.1.44 B.1.5 B.1.5.1 B.1.5.2 B.1.5.3 B.1.5.4 B.1.5.5 B.1.5.6 B.1.6 B.1.66 B.1.67 B.1.69 B.1.70 B.1.71 B.1.72 B.1.8 B.10 B.13 B.14 B.15 B.16 B.2 B.2.1 B.2.2 B.2.4 B.2.5 B.2.6 B.2.7 B.3 B.4 B.5 B.6 B.7 B.9 Details
Mutations from Bat RaTG13 info_outline
Position AA from AA to Chain Frequency (%) Depth (Å) Phi (°) Psi (°) RSA (%) SST MTR Score Consurf Score ΔAtomic Fluctuation (Å) ΔEnergy Deformation (kcal/mol) ΔΔGmCSMstability ΔΔGDynaMutstability ΔΔGDUETstability ΔΔGSDMstability ΔΔGENCoMstability ΔΔSENCoMvib Hydrophobics Positives Negatives Acceptors Donnors Aromatics Sulfurs Neutral Hydrogen bond Ionic Aromatic Hydrophobic Carbonyl Polar Pi blosum100 blosum30 blosum35 blosum40 blosum45 blosum50 blosum55 blosum60 blosum62 blosum65 blosum70 blosum75 blosum80 blosum85 blosum90 blosum95 pam120 pam180 pam250 pam30 pam300 pam60 pam90 HENS920102 HENS920103 WEIL970102 HENS920101 GRAR740104 PRLA000102 HENS920104 WEIL970101 GIAG010101 RISJ880101 DOSZ010102 DOSZ010103 JOND940101 DOSZ010101 ZHAC000101 MIYS990106 ZHAC000103 LIWA970101 QU_C930103 QU_C930102 QU_C930101 ZHAC000106 ZHAC000104 MIYS850102 MIYS850103 MIYS990107 GODA950101 BRYS930101 RIER950101 KOSJ950110_RSA JOND920103 VOGG950101 KESO980102 OGAK980101 NIEK910102 AZAE970101 AZAE970102 NIEK910101 TUDE900101 CROG050101 MIYS930101 MIYS960101 SIMK990105 SIMK990104 TOBD000102 BETM990101 TOBD000101 KOLA920101 MEHP950102 MEHP950101 PRLA000101 JOHM930101 QUIB020101 ROBB790102 MIRL960101 GEOD900101 KOSJ950100_SST DAYM780302 DAYM780301 LUTR910106 LUTR910107 LUTR910104 LUTR910105 LUTR910102 LUTR910103 THOP960101 LUTR910101 GONG920101 MCLA710101 LUTR910108 LUTR910109 SKOJ970101 SKOJ000101 OVEJ920101 KANM000101 VENM980101 RUSR970103 RUSR970102 RUSR970101 LINK010101 MUET010101 KOLA930101 MCLA720101 ALTS910101 LEVJ860101 BONM030101 BONM030106 MOOG990101 BONM030105 ZHAC000105 KAPO950101 OVEJ920100_RSA FEND850101 NGPC000101 SIMK990103 KESO980101 SKOJ000102 TANS760101 TANS760102 MIYT790101 BLAJ010101 PARB960101 CSEM940101 OVEJ920102 OVEJ920103 BONM030103 PARB960102 MICC010101 BONM030102 KOSJ950100_RSA_SST DOSZ010104 MUET020101 MUET020102 ZHAC000102 SIMK990102 NAOD960101 SIMK990101 MEHP950103 MIYS960102 MIYS960103 BONM030104 KOSJ950115 BASU010101 BENS940104 BENS940102 BENS940103 BENS940101 FITW660101 MOHR870101 A A.1 A.1.1 A.1.3 A.2 A.3 A.4 A.5 A.6 B B.1 B.1.1 B.1.1.1 B.1.1.10 B.1.1.13 B.1.1.14 B.1.1.17 B.1.1.18 B.1.1.2 B.1.1.3 B.1.1.4 B.1.1.5 B.1.1.6 B.1.1.7 B.1.1.8 B.1.1.9 B.1.12 B.1.13 B.1.19 B.1.22 B.1.23 B.1.26 B.1.29 B.1.3 B.1.30 B.1.31 B.1.32 B.1.33 B.1.34 B.1.35 B.1.36 B.1.37 B.1.38 B.1.39 B.1.40 B.1.41 B.1.43 B.1.44 B.1.5 B.1.5.1 B.1.5.2 B.1.5.3 B.1.5.4 B.1.5.5 B.1.5.6 B.1.6 B.1.66 B.1.67 B.1.69 B.1.70 B.1.71 B.1.72 B.1.8 B.10 B.13 B.14 B.15 B.16 B.2 B.2.1 B.2.2 B.2.4 B.2.5 B.2.6 B.2.7 B.3 B.4 B.5 B.6 B.7 B.9 Details
Normal Mode Analysis
Porcupine Plots info_outline
Modes Visualisation info_outline
Deformation Energy info_outline
Atomic Fluctuation info_outline
Molecular Dynamics