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About dendPoint

DendPoint is a novel computational method and database for predicting pharmacokinetic properties of dendrimer nanoparticles.

It is a machine learning approach that relies on a novel manually curated, literature derived relational database linking dendrimer physicochemical properties and pharmacokinetic parameters, including half life, clearance, dose in liver and urine.

Submission page - Single Prediction

How to run a prediction

To run a prediction:

• Click on "Predict" (1) to open the submission page.
• Provide Construct Properties (2).
• Provide Surface Functional Groups information (3).
• You can submit your query for analysis by clicking on (4).

Categorical and numerical descriptors:

• Surface charge ranges from highly anionic [---] to highly cationic [+++], and was collected based on discussion in the respective manuscriptss of the number and type of surface charge and surface PEG loading.


• Structural flexibility of the dendrimers ranges from relatively rigid [0] to highly flexible [+++] and was collected based on discussion in the respective manuscripts.


• Generation values within the database range from 1 to 7, however predictions are not limited to this interval.


• Construct Molecular Weight values within the database range from 2 to 334 KDa, however predictions are not limited to this interval.


• Typical ranges for different Functional Surface Groups can be inspected by browsing the database, however predictions are not limited to these intervals.

Results page - Single Prediction

Results

• The predicted pharmacokinetic properties will be displayed at the top panel (1).


• User have the option to run another prediction (2) or to run a comparison with another dendrimer (3).


• A depiction of the dendrimer structure, generation and surface functional groups is also displayed (4).


• In addition, a curve fort the predicted Plasma Concentration over time is available (5).

For Liver Clearance and Urinary Excretion a threshold of 20% defines whether a dendrimer is assigned as:
- Uptaken by liver/Excreted in urine (≤20%) or
- Limited liver uptake/Limited urinary excretion (>20%).

Submission page - Dendrimer Comparison

How to run a prediction

To run a prediction:

• After clicking on "Compare" to open the submission page, provide the Construct Properties for the first (1) and and second dendrimer (2).


• Provide the information regarding Surface Functional Groups for the first (3) and and second dendrimer (4).


• You are then ready to submit your query for analysis by clicking on (5).

Results page

Results - Dendrimer Comparison

• The predicted pharmacokinetic properties for the both dendrimers will be displayed at the top-left panel (1).


• A curve fort the predicted Plasma Concentration over time for both dendrimers will be available at the top-right panel(2).


• A depiction of the fisrt (3) and second dendrimer structure (4), depicting generation and surface functional groups are also displayed.

Contact page

Getting in touch

In case you experience any trouble using kamp or have any suggestions or comments, please do not hesitate in contacting us either via e-mail (1) or through the online form (2) .