dendPoint - Dendrimer Pharmacokinetics Prediction




Scaffold Generation Construct Molecular Weight (KDa) Relative Surface Charge Relative Structure Flexibility #Surface group (PEG) PEG Molecular Weight (KDa) Total PEG Molecular Weight (KDa) %Total PEG Molecular Weight #Surface group (non-PEG Sites) #Surface group (OH) #Surface group (NH2) #Surface group (Drug) #Surface group (Ac) #Surface group (do3a-Gd) #Surface group (Sulphates) #Surface group (CNNH2) Surface Drug % Dose in Liver % Dose in Urine Volume of Distribution (mL/kg) Half-life (hours) Clearance (mL/h/kg) Reference
PAMAM 3 8 3 0 0 0 0 0 32 0 29 0 0 0 0 0 NA 4 NA 115.44 2 40 link
PAMAM 2 21 0 0 7 2 14 0.67 5 0 0 0 0 5 0 0 NA 7 30 NA 6 NA link
PAMAM 2 24 0 0 3 5 15 0.63 9 0 0 0 0 9 0 0 NA 1 38 NA 0.6 NA link
PAMAM 5 29 0 0 0 0 0 0 128 128 0 0 0 0 0 0 NA 12 NA 2164.50 3 500 link
PAMAM 3 33 0 0 24 1 24 0.73 8 0 5 0 0 0 0 0 NA 4 NA 77.92 18 3 link
PAMAM 3 33 0 0 9 2 18 0.55 15 0 0 0 0 15 0 0 NA 4 NA NA 3 NA link
PAMAM 4 36 0 0 0 0 0 0 64 0 0 0 64 0 0 0 NA 4 NA 103.90 2 36 link
PAMAM 5 41 0 0 0 0 0 0 128 0 28 0 81 0 0 0 NA 57 NA 329.00 19 12 link
PAMAM 4 50 0 0 0 0 0 0 64 0 7 0 0 57 0 0 NA 40 35 1350.65 72 13 link
PAMAM 5 52 1 0 10 2 20 0.38 118 0 44 0 74 0 0 0 NA 15 2 40.40 14 2 link
PAMAM 6 58 0 0 0 0 0 0 256 256 0 0 0 0 0 0 NA 35 NA 1443.00 4 250 link
PAMAM 3 69 0 0 12 5 60 0.87 12 0 2 0 0 10 0 0 NA 8 NA NA 20 NA link
PAMAM 7 117 0 0 0 0 0 0 512 512 0 0 0 0 0 0 NA 7 NA 432.90 6 50 link
PAMAM 4 162 0 0 63 2 126 0.78 1 0 0 0 1 0 0 0 NA 7 NA 177.49 41 3 link
PAMAM 5 284 0 0 110 2 220 0.77 5 0 0 0 5 0 0 0 NA 7 NA 134.20 31 3 link
PAMAM 4 334 0 0 60 5 300 0.9 4 0 0 0 4 0 0 0 NA 6 NA 112.55 78 1 link
polyester 1 22 0 3 2 10 20 0.91 2 2 0 0 0 0 0 0 NA 1 33 1189.03 8 103 link
polyester 2 23 0 2 4 5 20 0.87 4 4 0 0 0 0 0 0 NA 2 22 333.33 11 21 link
polyester 2 43 0 2 4 10 40 0.93 4 4 0 0 0 0 0 0 NA 6 34 150.07 26 4 link
polyester 1 44 0 3 2 20 40 0.91 2 2 0 0 0 0 0 0 NA 2 20 219.34 1 152 link
polyester 3 45 0 1 8 5 40 0.89 8 8 0 0 0 0 0 0 NA 4 3 134.20 31 3 link
polyester 3 85 0 1 8 10 80 0.94 8 8 0 0 0 0 0 0 NA 6 2 115.44 40 2 link
polyester 2 87 0 2 4 20 80 0.92 4 4 0 0 0 0 0 0 NA 2 10 108.23 25 3 link
polyester 3 160 0 1 8 20 160 1 8 8 0 0 0 0 0 0 NA 2 7 144.30 50 2 link
polyglycerol 2 6 0 0 0 0 0 0 16 16 0 0 0 0 0 0 NA 8 55 323.23 16 14 link
polyglycerol 2 9 -1 0 0 0 0 0 16 10 0 0 0 0 6 0 NA 90 5 80.81 1 56 link
polyglycerol 2 13 -2 0 0 0 0 0 16 3 0 0 0 0 13 0 NA 76 1 92.35 1 64 link
polylysine 3 2 3 1 0 0 0 0 16 0 16 0 0 0 0 0 NA 5 8 280.23 0.1 1942 link
polylysine 4 4 3 1 0 0 0 0 32 0 32 0 0 0 0 0 NA 24 4 415.58 0.1 2880 link
polylysine 4 4 3 1 0 0 0 0 32 0 32 0 0 0 0 0 NA 10 4 668.11 0.1 4630 link
polylysine 4 5 -2 1 0 0 0 0 32 0 0 0 0 0 0 0 NA 12 25 92.21 0.9 71 link
polylysine 3 6 0 1 16 0.2 3.2 0.53 0 0 0 0 0 0 0 0 NA 0 82 560.17 0.6 647 link
polylysine 4 7 -3 1 0 0 0 0 32 0 0 0 0 0 32 0 NA 0 63 501.01 0.2 1736 link
polylysine 4 10 -3 1 0 0 0 0 16 0 0 0 0 0 16 0 NA 26 30 27.27 0.9 21 link
polylysine 4 11 0 1 32 0.2 6.4 0.58 0 0 0 0 0 0 0 0 NA 0 80 386.87 0.7 383 link
polylysine 3 11 0 0 8 0.57 4.56 0.41 8 0 0 8 0 0 0 0 MTX 1 56 63.92 0.1 443 link
polylysine 4 13 2 1 16 0.57 9.12 0.7 16 0 16 0 0 0 0 0 NA 3 74 30.74 0.1 213 link
polylysine 4 14 0 1 16 0.57 9.12 0.65 16 0 0 0 16 0 0 0 NA 0.3 72 206.78 0.1 1433 link
polylysine 4 14 -3 1 0 0 0 0 32 0 0 0 0 0 32 0 NA 49 3 34.63 1 24 link
polylysine 3 15 0 0 8 1 8 0.53 8 0 0 8 0 0 0 0 MTX 1 64 95.24 0.2 330 link
polylysine 4 21 0 0 16 0.57 9.12 0.43 16 0 0 16 0 0 0 0 MTX 1 29 99.86 0.4 173 link
polylysine 4 22 0 0 32 0.57 18.24 0.83 0 0 0 0 0 0 0 0 NA 2 33 181.82 14 9 link
polylysine 4 22 0 1 32 0.57 18.24 0.83 0 0 0 0 0 0 0 0 NA 2 43 245.31 10 17 link
polylysine 5 27 2 1 18 1 18 0.67 55 0 55 0 0 0 0 0 NA 5 24 86.58 30 2 link
polylysine 4 30 0 0 16 1 16 0.53 16 0 0 16 0 0 0 0 MTX 7 24 151.52 21 5 link
polylysine 5 31 1 1 18 1 18 0.58 46 0 23 0 0 0 0 23 NA 3 16 108.23 25 3 link
polylysine 3 34 0 1 16 2 32 0.94 0 0 0 0 0 0 0 0 NA 4 26 103.90 24 3 link
polylysine 5 36 1 1 18 1 18 0.5 46 0 23 15 0 0 0 8 dox 5 13 101.01 35 2 link
polylysine 5 41 2 1 28 1 28 0.68 36 0 36 0 0 0 0 0 NA 37 4 585.86 29 14 link
polylysine 5 42 0 0 32 0.57 18.24 0.43 32 0 0 32 0 0 0 0 MTX 10 2 173.16 24 5 link
polylysine 5 45 1 1 28 1 28 0.62 36 0 16 0 0 0 0 20 NA 4 4 95.24 22 3 link
polylysine 4 47 0 0 16 2.3 36.8 0.78 16 0 0 16 0 0 0 0 MTX 10 8 98.12 34 2 link
polylysine 5 48 0 0 64 0.57 36.48 0.76 0 0 0 0 0 0 0 0 NA 8 6 53.39 37 1 link
polylysine 5 53 1 1 28 1 28 0.53 36 0 16 15 0 0 0 5 dox 9 3 98.12 34 2 link
polylysine 5 56 0 1 30 1 30 0.54 34 0 4 15 0 0 0 15 dox NA NA 73.59 51 1 link
polylysine 5 59 0 0 32 1 32 0.54 32 0 0 32 0 0 0 0 MTX 12 1 147.19 51 2 link
polylysine 5 64 -1 1 32 1 32 0.5 32 0 0 0 0 0 0 0 NA 16 16 142.86 33 3 link
polylysine 5 64 -1 0 32 1 32 0.5 32 0 6 26 0 0 0 0 MTX 52 2 34.63 1 24 link
polylysine 5 64 0 0 32 1 32 0.5 32 0 6 26 0 0 0 0 MTX 8 9 75.04 26 2 link
polylysine 4 68 0 1 32 2 64 0.94 0 0 0 0 0 0 0 0 NA 9 3 108.23 75 1 link
polylysine 5 68 -1 1 32 1 32 0.47 32 0 8 24 0 0 0 0 MTX 85 2 28.14 0.3 65 link
polylysine 5 71 0 1 32 1 32 0.45 32 0 4 28 0 0 0 0 MTX 10 14 95.24 33 2 link
Triazine 2 11 0 0 14 0.6 8.4 0.76 10 8 2 0 0 0 0 0 NA 16 16 190.91 27 4.9 link
Triazine 2 30 0 0 13 2 26 0.87 11 8 3 0 0 0 0 0 NA 12 10 167.53 43 2.7 link
Triazine 2 34 0 0 7 2 13 0.38 18 0 6 12 0 0 0 0 pac 10 41 173.16 20 6 link
Triazine 2 37 0 0 8 2 16 0.43 16 0 4 12 0 0 0 0 pac 22 55 246.75 19 9 link
Triazine 2 39 0 0 9 2 18 0.46 15 0 3 12 0 0 0 0 pac 11 35 303.03 15 14 link
Triazine 2 61 0 0 7 5 32.5 0.53 18 0 0 16 0 0 0 0 pac 20 5 76.77 38 1.4 link
Triazine 2 73 0 0 10 5 50 0.68 14 8 6 0 0 0 0 0 NA 10 9 144.30 100 1 link

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