Skin sensitisation is a commonly evaluated adverse effect for dermally applied products. This endpoint evaluates if a compound will cause/induce allergic reaction while in contact with the dermatitis. Therefore, it will provide guidance for classifying if a compound will yield skin sensitisation or not.
Title : Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization and their application to identify potentially hazardous compounds
Authors : Alves, Vinicius M., Eugene Muratov, Denis Fourches, Judy Strickland, Nicole Kleinstreuer, Carolina H. Andrade, and Alexander Tropsha
URL : https://www.sciencedirect.com/science/article/pii/S0041008X14004529
Journal : Toxicology and Applied Pharmacology
Year : 2015