In this endpoint, it is evaluated the toxic potency of a compound, by evaluating its lethal dosage (LD50). This is a standard measurement of acute toxicity. The LD50 is the amount of a compound given to all at once that causes the death of 50% of a group of test animals (rats, in this particular case).
Title : Quantitative Structure−Activity Relationship Modeling of Rat Acute Toxicity by Oral Exposure
Authors : Zhu, Hao, Todd M. Martin, Lin Ye, Alexander Sedykh, Douglas M. Young, and Alexander Tropsha
URL : https://pubs.acs.org/doi/10.1021/tx900189p
Journal : Chemical Research in Toxicology
Year : 2009