Molecular compounds inducing liver injury present major safety concerns while assessing ADMET properties for drugs. This endpoint data is defined upon the analysis of this aspect, mapping when one pathological or physiological liver event (i.e., an event that causes disruption of the normal function of the liver) is strongly associated with the use of a compound.
Title : Cheminformatics Analysis of Assertions Mined from Literature That Describe Drug-Induced Liver Injury in Different Species
Authors : Fourches, Denis, Julie C. Barnes, Nicola C. Day, Paul Bradley, Jane Z. Reed, and Alexander Tropsha
URL : https://pubs.acs.org/doi/10.1021/tx900326k
Journal : Chemical Research in Toxicology
Year : 2010