The inhibition of the potassium channels encoded by hERG (human ether-go-go gene) is one of the main causes for the emergence of acquired long QT syndrome, which can lead to fatal ventricular arrhythmia. Therefore, analysing if a chemical compound can affect or not these channels is essential for heart toxicity/cardiotoxicity purposes. It is worth noting that this endpoint characterizes compounds that can inhibit hERG II.
admetSAR:
URL 1, 2012: http://lmmd.ecust.edu.cn/admetsar1
URL 2, 2018: http://lmmd.ecust.edu.cn/admetsar2
Title : Development of binary classification models for prediction of hERG potassium channel blockage
Authors : Wang, Sichao, Youyong Li, Junmei Wang, Lei Chen, Liling Zhang, Huidong Yu, and Tingjun Hou
URL : https://pubs.acs.org/doi/full/10.1021/mp300023x
Journal : Molecular Pharmaceutics
Year : 2012