The inhibition of the potassium channels encoded by hERG (human ether-go-go gene) is one of the main causes for the emergence of acquired long QT syndrome, which can lead to fatal ventricular arrhythmia. Therefore, analysing if a chemical compound can affect or not these channels is essential for heart toxicity purposes. It is worth noting that this endpoint characterizes compounds that can inhibit hERG I.
admetSAR:
URL 1, 2012: http://lmmd.ecust.edu.cn/admetsar1
URL 2, 2018: http://lmmd.ecust.edu.cn/admetsar2
Title : Development and Comparison of hERG Blocker Classifiers: Assessment on Different Datasets Yields Markedly Different Results
Authors : Marchese Robinson, Richard L., Robert C. Glen, and John BO Mitchell
URL : https://onlinelibrary.wiley.com/doi/10.1002/minf.201000159
Journal : Molecular Informatics
Year : 2011