Toxicity is defined by genotoxicity tests, and it is mapped in this endpoint by the Ames test, a widely used method to assess compound mutagenic using bacteria. A positive case indicates mutagenic and therefore may act as a carcinogen.
Title : In Silico Estimation of Chemical Carcinogenicity with Binary and Ternary Classification Methods
Authors : Li, Xiao, Zheng Du, Jie Wang, Zengrui Wu, Weihua Li, Guixia Liu, Xu Shen, and Yun Tang
URL : https://onlinelibrary.wiley.com/doi/abs/10.1002/minf.201400127
Journal : Molecular Informatics
Year : 2015