toxCSM Endpoint: AMES Mutagenesis


Description


Toxicity is defined by genotoxicity tests, and it is mapped in this endpoint by the Ames test, a widely used method to assess compound mutagenic using bacteria. A positive case indicates mutagenic and therefore may act as a carcinogen.


Data Acquisition and Reference


Title : In silico Prediction of Chemical Ames Mutagenicity
Authors : Xu, Congying, Feixiong Cheng, Lei Chen, Zheng Du, Weihua Li, Guixia Liu, Philip W. Lee, and Yun Tang
URL : https://pubs.acs.org/doi/full/10.1021/ci300400a
Journal : Toxicology Research
Year : 2012