ORF6 - Mutation K23R on chain A
Mutation Details
ΔΔGstability DUET: -0.24 kcal.mol-1 (destabilising)
ΔΔGstability SDM: 0.04 kcal.mol-1 (neutral)
ΔΔGstability ENCoM: 0.06 kcal.mol-1 (destabilising)
ΔΔGstability DynaMut: -0.7 kcal.mol-1 (destabilising)
ΔAtomic FluctuationWild-type - Mutant: 0.0Å
ΔDeformation EnergyWild-type - Mutant: 21.26Å
Chain: A
Position: 23
Wild-type: LYS
Mutant: ARG
Depth: 2.1Å
SST: Turn
Mutation Frequency: < 0.01
Δ Vibrational Entropy Energy | Visual representation
ΔΔSVib ENCoM: -0.08 kcal.mol-1.K-1
(Decrease molecule flexibility)
ΔPharmacophores:
0
-1
0
0
-2
0
0
0
Difference in molecular interactions between LYS and ARG:
| Hydrogen Bond | Ionic | Aromatic | Hydrophobic | Carbonyl | Polar | PI |
|---|---|---|---|---|---|---|
| 1 | 0 | 0 | -1 | 0 | -1 | 0 |
Co-occurring variants info_outline
| Protein | Mutation | Chain | Co-occurrence rate (%) | Depth (Å) | Phi (°) | Psi (°) | RSA (%) | SST | Details |
|---|