Surface glycoprotein (Spike) - Mutation A672V on chain A
Mutation Details

ΔΔGstability mCSM: -0.34 kcal.mol-1 (destabilising)

ΔΔGstability DUET: 0.31 kcal.mol-1 (stabilising)

ΔΔGstability SDM: 0.95 kcal.mol-1 (stabilising)

ΔΔGstability ENCoM: 0.34 kcal.mol-1 (neutral)

ΔΔGstability DynaMut: 2.13 kcal.mol-1 (stabilising)

ΔPPI AffinitymCSM: -0.71 kcal.mol-1 (decrease affinity)

ΔAtomic FluctuationWild-type - Mutant: -0.0Å

ΔDeformation EnergyWild-type - Mutant: 0.01Å

Chain: A

Position: 672

Wild-type: ALA

Mutant: VAL

Depth: 5.06Å

SST: Strand

Distance to PPI interface: 6.2Å

Mutation Frequency: 0.03

Δ Vibrational Entropy Energy | Visual representation

ΔΔSVib ENCoM: -0.43 kcal.mol-1.K-1

(Decrease molecule flexibility)

ΔPharmacophores:

-2 0 0 0 0 0 0 0

Difference in molecular interactions between ALA and VAL:

Hydrogen Bond Ionic Aromatic Hydrophobic Carbonyl Polar PI
-1 0 0 -14 0 -2 0
Contacts

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Co-occurring variants info_outline
Protein Mutation Chain Co-occurrence rate (%) Depth (Å) Phi (°) Psi (°) RSA (%) SST Details