Surface glycoprotein (Spike) - Mutation T761A on chain A
Mutation Details

ΔΔGstability mCSM: -0.51 kcal.mol-1 (destabilising)

ΔΔGstability DUET: 0.21 kcal.mol-1 (stabilising)

ΔΔGstability SDM: 1.53 kcal.mol-1 (stabilising)

ΔΔGstability ENCoM: -0.03 kcal.mol-1 (destabilising)

ΔΔGstability DynaMut: 0.13 kcal.mol-1 (neutral)

ΔPPI AffinitymCSM: -0.06 kcal.mol-1 (neutral)

ΔAtomic FluctuationWild-type - Mutant: -0.0Å

ΔDeformation EnergyWild-type - Mutant: 0.0Å

Chain: A

Position: 761

Wild-type: THR

Mutant: ALA

Depth: 1.86Å

SST: α-helix

Distance to PPI interface: 4.6Å

Mutation Frequency: < 0.01

Δ Vibrational Entropy Energy | Visual representation

ΔΔSVib ENCoM: 0.04 kcal.mol-1.K-1

(Increase molecule flexibility)

ΔPharmacophores:

0 0 0 0 1 0 0 1

Difference in molecular interactions between THR and ALA:

Hydrogen Bond Ionic Aromatic Hydrophobic Carbonyl Polar PI
- - - - - - -
Contacts

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Co-occurring variants info_outline
Protein Mutation Chain Co-occurrence rate (%) Depth (Å) Phi (°) Psi (°) RSA (%) SST Details