Surface glycoprotein (Spike) - Mutation D614G on chain A
Mutation Details

ΔΔGstability mCSM: -0.28 kcal.mol-1 (destabilising)

ΔΔGstability DUET: 0.46 kcal.mol-1 (stabilising)

ΔΔGstability SDM: 2.33 kcal.mol-1 (stabilising)

ΔΔGstability ENCoM: 0.01 kcal.mol-1 (destabilising)

ΔΔGstability DynaMut: 0.34 kcal.mol-1 (stabilising)

ΔPPI AffinitymCSM: -0.22 kcal.mol-1 (decrease affinity)

ΔAtomic FluctuationWild-type - Mutant: -0.0Å

ΔDeformation EnergyWild-type - Mutant: 0.0Å

Chain: A

Position: 614

Wild-type: ASP

Mutant: GLY

Depth: 1.67Å

SST: Turn

Distance to PPI interface: 3.8Å

Mutation Frequency: 73.83

Δ Vibrational Entropy Energy | Visual representation

ΔΔSVib ENCoM: -0.01 kcal.mol-1.K-1

(Decrease molecule flexibility)

ΔPharmacophores:

1 0 2 2 0 0 0 1

Difference in molecular interactions between ASP and GLY:

Hydrogen Bond Ionic Aromatic Hydrophobic Carbonyl Polar PI
0 0 0 0 0 0 0
Contacts

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Co-occurring variants info_outline
Protein Mutation Chain Co-occurrence rate (%) Depth (Å) Phi (°) Psi (°) RSA (%) SST Details
Mutation Effects on Dynamics - Normal Mode Analysis info_outline