Non-structural protein 6 (nsp6) - Mutation A2E on chain A
Mutation Details

ΔΔGstability mCSM: -0.55 kcal.mol-1 (destabilising)

ΔΔGstability DUET: -0.15 kcal.mol-1 (neutral)

ΔΔGstability SDM: 0.06 kcal.mol-1 (neutral)

ΔΔGstability ENCoM: 0.31 kcal.mol-1 (neutral)

ΔΔGstability DynaMut: 0.37 kcal.mol-1 (stabilising)

ΔAtomic FluctuationWild-type - Mutant: -0.1Å

ΔDeformation EnergyWild-type - Mutant: 70.14Å

Chain: A

Position: 2

Wild-type: ALA

Mutant: GLU

Depth: 1.85Å

SST: -

Mutation Frequency: < 0.01

Δ Vibrational Entropy Energy | Visual representation

ΔΔSVib ENCoM: -0.38 kcal.mol-1.K-1

(Decrease molecule flexibility)

ΔPharmacophores:

-1 0 -2 -2 0 0 0 -1

Difference in molecular interactions between ALA and GLU:

Hydrogen Bond Ionic Aromatic Hydrophobic Carbonyl Polar PI
0 0 0 0 0 1 0
Contacts

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Co-occurring variants info_outline
Protein Mutation Chain Co-occurrence rate (%) Depth (Å) Phi (°) Psi (°) RSA (%) SST Details