Uridylate-specific endoribonuclease (NendoU) - Mutation T114N on chain C
Mutation Details

ΔΔGstability mCSM: -0.16 kcal.mol-1 (neutral)

ΔΔGstability DUET: -0.07 kcal.mol-1 (neutral)

ΔΔGstability SDM: 0.16 kcal.mol-1 (neutral)

ΔΔGstability ENCoM: -0.14 kcal.mol-1 (destabilising)

ΔΔGstability DynaMut: -0.17 kcal.mol-1 (neutral)

ΔPPI AffinitymCSM: -0.29 kcal.mol-1 (decrease affinity)

ΔAtomic FluctuationWild-type - Mutant: -0.05Å

ΔDeformation EnergyWild-type - Mutant: -3.25Å

Chain: C

Position: 114

Wild-type: THR

Mutant: ASN

Depth: 1.81Å

SST: Turn

Distance to PPI interface: 2.62Å

Mutation Frequency: < 0.01

Δ Vibrational Entropy Energy | Visual representation

ΔΔSVib ENCoM: 0.17 kcal.mol-1.K-1

(Increase molecule flexibility)

ΔPharmacophores:

0 0 0 -1 -1 0 0 0

Difference in molecular interactions between THR and ASN:

Hydrogen Bond Ionic Aromatic Hydrophobic Carbonyl Polar PI
0 0 0 1 0 0 0
Contacts

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Co-occurring variants info_outline
Protein Mutation Chain Co-occurrence rate (%) Depth (Å) Phi (°) Psi (°) RSA (%) SST Details