Helicase (Hel) - Mutation F587C on chain A
Mutation Details

ΔΔGstability mCSM: -2.02 kcal.mol-1 (destabilising)

ΔΔGstability DUET: -2.14 kcal.mol-1 (destabilising)

ΔΔGstability SDM: -1.37 kcal.mol-1 (destabilising)

ΔΔGstability ENCoM: -0.61 kcal.mol-1 (destabilising)

ΔΔGstability DynaMut: -1.14 kcal.mol-1 (destabilising)

ΔAtomic FluctuationWild-type - Mutant: -0.0Å

ΔDeformation EnergyWild-type - Mutant: -0.03Å

Chain: A

Position: 587

Wild-type: PHE

Mutant: CYS

Depth: 3.56Å

SST: Bend

Mutation Frequency: < 0.01

Δ Vibrational Entropy Energy | Visual representation

ΔΔSVib ENCoM: 0.77 kcal.mol-1.K-1

(Increase molecule flexibility)

ΔPharmacophores:

6 0 0 0 0 6 -1 -1

Difference in molecular interactions between PHE and CYS:

Hydrogen Bond Ionic Aromatic Hydrophobic Carbonyl Polar PI
-1 0 0 24 0 0 4
Contacts

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Co-occurring variants info_outline
Protein Mutation Chain Co-occurrence rate (%) Depth (Å) Phi (°) Psi (°) RSA (%) SST Details