Replicase Polyprotein 1ab - Mutation S778N on chain A
Mutation Details
ΔΔGstability mCSM: -0.53 kcal.mol-1 (destabilising)
ΔΔGstability DUET: -0.21 kcal.mol-1 (destabilising)
ΔΔGstability SDM: 0.51 kcal.mol-1 (stabilising)
ΔΔGstability ENCoM: -0.08 kcal.mol-1 (destabilising)
ΔΔGstability DynaMut: 0.02 kcal.mol-1 (neutral)
ΔAtomic FluctuationWild-type - Mutant: -0.0Å
ΔDeformation EnergyWild-type - Mutant: 0.0Å
Chain: A
Position: 778
Wild-type: SER
Mutant: ASN
Depth: 2.61Å
SST: -
Mutation Frequency: < 0.01
Δ Vibrational Entropy Energy | Visual representation
ΔΔSVib ENCoM: 0.1 kcal.mol-1.K-1
(Increase molecule flexibility)
ΔPharmacophores:
-1
0
0
-1
-1
0
0
0
Difference in molecular interactions between SER and ASN:
| Hydrogen Bond | Ionic | Aromatic | Hydrophobic | Carbonyl | Polar | PI |
|---|---|---|---|---|---|---|
| -1 | 0 | 0 | 0 | 0 | 0 | -1 |
Co-occurring variants info_outline
| Protein | Mutation | Chain | Co-occurrence rate (%) | Depth (Å) | Phi (°) | Psi (°) | RSA (%) | SST | Details |
|---|