Replicase Polyprotein 1ab - Mutation Q698K on chain A
Mutation Details
ΔΔGstability mCSM: -0.66 kcal.mol-1 (destabilising)
ΔΔGstability DUET: -0.39 kcal.mol-1 (destabilising)
ΔΔGstability SDM: -0.54 kcal.mol-1 (destabilising)
ΔΔGstability ENCoM: 0.25 kcal.mol-1 (destabilising)
ΔΔGstability DynaMut: 0.6 kcal.mol-1 (stabilising)
ΔAtomic FluctuationWild-type - Mutant: 0.0Å
ΔDeformation EnergyWild-type - Mutant: -0.0Å
Chain: A
Position: 698
Wild-type: GLN
Mutant: LYS
Depth: 9.67Å
SST: α-helix
Mutation Frequency: < 0.01
Δ Vibrational Entropy Energy | Visual representation
ΔΔSVib ENCoM: -0.31 kcal.mol-1.K-1
(Decrease molecule flexibility)
ΔPharmacophores:
-1
-1
0
1
0
0
0
0
Difference in molecular interactions between GLN and LYS:
| Hydrogen Bond | Ionic | Aromatic | Hydrophobic | Carbonyl | Polar | PI |
|---|---|---|---|---|---|---|
| -2 | 0 | 0 | -7 | 0 | 0 | -9 |
Co-occurring variants info_outline
| Protein | Mutation | Chain | Co-occurrence rate (%) | Depth (Å) | Phi (°) | Psi (°) | RSA (%) | SST | Details |
|---|