Replicase Polyprotein 1ab - Mutation N911K on chain A
Mutation Details
ΔΔGstability mCSM: -0.22 kcal.mol-1 (destabilising)
ΔΔGstability DUET: 0.33 kcal.mol-1 (stabilising)
ΔΔGstability SDM: 0.43 kcal.mol-1 (stabilising)
ΔΔGstability ENCoM: 0.01 kcal.mol-1 (destabilising)
ΔΔGstability DynaMut: 0.44 kcal.mol-1 (stabilising)
ΔAtomic FluctuationWild-type - Mutant: -0.0Å
ΔDeformation EnergyWild-type - Mutant: 0.03Å
Chain: A
Position: 911
Wild-type: ASN
Mutant: LYS
Depth: 2.08Å
SST: α-helix
Mutation Frequency: < 0.01
Δ Vibrational Entropy Energy | Visual representation
ΔΔSVib ENCoM: -0.01 kcal.mol-1.K-1
(Decrease molecule flexibility)
ΔPharmacophores:
-2
-1
0
1
1
0
0
0
Difference in molecular interactions between ASN and LYS:
| Hydrogen Bond | Ionic | Aromatic | Hydrophobic | Carbonyl | Polar | PI |
|---|---|---|---|---|---|---|
| 5 | 0 | 0 | -2 | 0 | 1 | 0 |
Co-occurring variants info_outline
| Protein | Mutation | Chain | Co-occurrence rate (%) | Depth (Å) | Phi (°) | Psi (°) | RSA (%) | SST | Details |
|---|