Replicase Polyprotein 1ab - Mutation K143Q on chain A
Mutation Details
ΔΔGstability mCSM: -1.08 kcal.mol-1 (destabilising)
ΔΔGstability DUET: -0.79 kcal.mol-1 (destabilising)
ΔΔGstability SDM: -0.05 kcal.mol-1 (neutral)
ΔΔGstability ENCoM: -0.27 kcal.mol-1 (destabilising)
ΔΔGstability DynaMut: -0.43 kcal.mol-1 (destabilising)
ΔAtomic FluctuationWild-type - Mutant: 0.0Å
ΔDeformation EnergyWild-type - Mutant: 0.0Å
Chain: A
Position: 143
Wild-type: LYS
Mutant: GLN
Depth: 2.39Å
SST: α-helix
Mutation Frequency: < 0.01
Δ Vibrational Entropy Energy | Visual representation
ΔΔSVib ENCoM: 0.34 kcal.mol-1.K-1
(Increase molecule flexibility)
ΔPharmacophores:
1
1
0
-1
0
0
0
0
Difference in molecular interactions between LYS and GLN:
| Hydrogen Bond | Ionic | Aromatic | Hydrophobic | Carbonyl | Polar | PI |
|---|---|---|---|---|---|---|
| -1 | 0 | 0 | 8 | 0 | 1 | -1 |
Co-occurring variants info_outline
| Protein | Mutation | Chain | Co-occurrence rate (%) | Depth (Å) | Phi (°) | Psi (°) | RSA (%) | SST | Details |
|---|