Replicase Polyprotein 1ab - Mutation D164N on chain A
Mutation Details

ΔΔGstability mCSM: -1.0 kcal.mol-1 (destabilising)

ΔΔGstability DUET: -0.98 kcal.mol-1 (destabilising)

ΔΔGstability SDM: -0.41 kcal.mol-1 (destabilising)

ΔΔGstability ENCoM: 0.03 kcal.mol-1 (destabilising)

ΔΔGstability DynaMut: -0.04 kcal.mol-1 (neutral)

ΔAtomic FluctuationWild-type - Mutant: 0.0Å

ΔDeformation EnergyWild-type - Mutant: 0.0Å

Chain: A

Position: 164

Wild-type: ASP

Mutant: ASN

Depth: 2.38Å

SST: -

Mutation Frequency: < 0.01

Δ Vibrational Entropy Energy | Visual representation

ΔΔSVib ENCoM: -0.04 kcal.mol-1.K-1

(Decrease molecule flexibility)

ΔPharmacophores:

0 0 2 1 -2 0 0 0

Difference in molecular interactions between ASP and ASN:

Hydrogen Bond Ionic Aromatic Hydrophobic Carbonyl Polar PI
0 0 0 -2 0 4 0
Contacts

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Co-occurring variants info_outline
Protein Mutation Chain Co-occurrence rate (%) Depth (Å) Phi (°) Psi (°) RSA (%) SST Details