Stability Results

Free Gibbs Energy (ΔΔG) from wild-type:

-4.54 kcal/mol

Decreasing stability

Melting Temperature (ΔTm): None

Mutation Details

Position: 270 (Based on: PDB and Uniprot)

Wild-type: PHE

Mutant: CYS

Chain: A

Structure mutations: 0

Wild-type Environment

RSA: 0.01

SST: Strand

Phi: -150.7

Psi: 150.2

Depth: 5.85

Experimental Details

Temperature: 283.15

pH: 7.2

Method: Unavailable

Measure: Unavailable

Pharmacophore Vector

Substitution Matrices

Protein Details

Name: Cellular tumor antigen p53

Organism: Homo sapiens

Lenght:

Weight: None

Literature

REFERENCE: BIOMETRICS 4, 943-7 (1975)

Pubmed: 1203434

YEAR: 1975

Databases Links

UNIPROT: P04637

PDB: 1TUP

PROTEIN STRUCTURE JSON FILE