Stability Results

Free Gibbs Energy (ΔΔG) from wild-type:

-4.78 kcal/mol

Decreasing stability

Melting Temperature (ΔTm): None

Mutation Details

Position: 134 (Based on: PDB and Uniprot)

Wild-type: PHE

Mutant: LEU

Chain: A

Structure mutations: 0

Wild-type Environment

RSA: 0.0

SST: Strand

Phi: -115.6

Psi: 128.7

Depth: 6.55

Experimental Details

Temperature: 283.15

pH: 7.2

Method: Unavailable

Measure: Unavailable

Pharmacophore Vector

Substitution Matrices

Protein Details

Name: Cellular tumor antigen p53

Organism: Homo sapiens

Lenght:

Weight: None

Literature

REFERENCE: BIOMETRICS 4, 943-7 (1975)

Pubmed: 1203434

YEAR: 1975

Databases Links

UNIPROT: P04637

PDB: 1TUP

PROTEIN STRUCTURE JSON FILE