Kinact - Kinase Activating Mutation Predictor

Prediction Outcome

Mutation predicted outcome:


Effects of Mutation on Stability:

mCSM ΔΔG: -0.371 kcal/mol (Destabilizing)

SDM ΔΔG: -0.500 kcal/mol (Destabilizing)

DUET ΔΔG: -0.291 kcal/mol (Destabilizing)

Mutation details:

Chain: A

Position: 346

Wild-type: Glutamate (E)Structure of E

Mutant-type: Lysine (K)Structure of K

Protein details:

Secondary Structure: Strand

Relative Solvent Accessibility: 52.06%

Closest Group of Kinases: TKL

Families in this group 28

Superposition of structures in the closest group of kinases:


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Binding types
Binding Type
Weak Hbond
Metal Complex
Polar Hbond without angle

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Spectrum of conservation

Not conserved

Help! Use your mouse scroll to see all sequences of the alignment. The first sequence is the sequence submitted for the predictions and the other are the sequences of homologs from the same group of kinases. Only the last digit of residue numbers are shown due to visual purposes, but one can hover the cursor over any digit to see the exact number for an specific position.


Residue Type
Polar (QNSTYW)
Hydrophobic (AGILPVF)
Charged (RHKDE)
Sulphuretted (CM)

X: Activating mutation