Single-Point Mutation

Results

Predicted Affinity Change (ΔΔGAffinity wt->mt)

-6.104 kcal/mol

(Decreasing affinity)


Reverse Prediction (ΔΔGAffinity mt->wt)


0.101 Kcal/mol (Increasing affinity)

Mutation Details


Chain: I

Position: 45

Wild-type: LEU

Mutant: PRO

Distance from closest partner: 2.72Å

Interactive Viewer
Interactions

Clash

VDW

Hydrogen Bond

Ionic

Aromatic

Hydrophobic

Carbonyl

Polar

Interactions: Wild-Type x Mutant
Controls

Wild-Type (dashed lines)

Mutant (straight lines)

Carbonyl

Aromatic

Ionic

VDW

Hydrogen bonds

Hydrophobic

Polar Hbond

Clash

Ring-Ring