Single-Point Mutation

Results

Predicted Affinity Change (ΔΔGAffinity wt->mt)

-1.25 kcal/mol

(Decreasing affinity)


Mutation Details


Chain: A

Position: 161

Wild-type: ALA

Mutant: GLY

Ligand Details


ID: 01S

Wild-affinity: 6.72

Interactive Viewer
Interactions

Clash

VDW

Hydrogen Bond

Ionic

Aromatic

Hydrophobic

Carbonyl

Polar

Interactions: Wild-Type x Mutant
Controls

Wild-Type (dashed lines)

Mutant (straight lines)

Carbonyl

Aromatic

Ionic

VDW

Hydrogen bonds

Hydrophobic

Polar

Clash

Node Importance
Color Map Blue Color Map Red
Protein-Ligand Importance Protein-Ligand Importance