Alanine Scanning
Predictions for Binding Site Residues
| # | Chain | Wild Type | Position | Mutant | Predicted ΔΔGAffinity (kcal/mol) | Affinity |
|---|---|---|---|---|---|---|
| 1 | A | Y | 219 | A | -2.26 | Decreasing |
| 2 | A | H | 162 | A | -1.53 | Decreasing |
| 3 | A | G | 158 | A | -1.78 | Decreasing |
| 4 | A | L | 193 | A | -2.71 | Decreasing |
| 5 | A | L | 160 | A | -2.7 | Decreasing |
| 6 | A | H | 197 | A | -1.74 | Decreasing |
| 7 | A | P | 217 | A | -1.58 | Decreasing |
| 8 | A | V | 194 | A | -1.15 | Decreasing |
| 9 | A | N | 218 | A | -1.36 | Decreasing |
| 10 | A | Y | 216 | A | -2.07 | Decreasing |
| 11 | A | L | 214 | A | -2.27 | Decreasing |
| 12 | A | H | 201 | A | -1.74 | Decreasing |
| 13 | A | H | 207 | A | -1.68 | Decreasing |
| 14 | A | E | 198 | A | -2.3 | Decreasing |
| 15 | A | I | 159 | A | -1.89 | Decreasing |
Bar Chart