Welcome to TIRome

TIRome is a grammar-based discovery engine for structural mimicry across the global TIRome. Rather than relying only on global similarity (e.g., TM-score), TIRome anchors each hit to a reference TIR domain and audits where the fold agrees using a tiered structural grammar (scaffold vs loop variation). This produces an interpretable “scaffold score” with tier labels, enabling rapid discovery of proteins that preserve TIR-like signalling architecture even when overall geometry is highly divergent. The resource provides an interactive atlas of 1,745 precomputed candidate mimics with linked structure viewing, alignment deconvolution, and distribution-level context.