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"MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ", "variant_pos": "[67]", "length": null, "PDBs_template": null, "regions": "[[67, 267]]", "source": {"name": "Homo sapiens"}, "num_struc_mut": 1, "swissprot": null, "FASTA_path": null, "uniprot": "P02647", "PIR_ID": null}, "id": 4833, "aro": null, "reference": {"PMID": "10572013", "DOI": "10.1021/bi991428h", "description": "BIOCHEMISTRY 43, 14387-95 (1999)", "year": 1999}, "ca_depth": null, "mut_count": 3, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "W8F,W50F,W72F,W108F", "mutation_based": "Uniprot", "blosum62": 0, "neu": null, "ddg": -1.14, "method": {"name": "GdnHCl"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": 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"sequence": "MALKSLVLLSLLVLVLLLVRVQPSLGKETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[27, 150]]", "source": {"name": "Bos taurus"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P61823", "PIR_ID": null}, "id": 6583, "aro": null, "reference": {"PMID": "12538908", "DOI": "10.1093/protein/15.11.887", "description": "PROTEIN ENG 11, 887-93 (2002)", "year": 2002}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "Q37E, D44G, S45N", "mutation_based": "unsigned", "blosum62": null, "neu": null, "ddg": null, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": 326.85, "acc": null, "don": null, "dtm": -4.4, "pam250": null, "relative_bfactor": null, "ph": 5.0}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "DSC"}, "protein": {"PDB_path": null, "PDB_wild": "1AJ3", "name": "Spectrin alpha chain, non-erythrocytic 1", "sequence": "MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSSLRRQKLEDSYRFQFFQRDADELGKWIQEKLQIASDENYKDPSNLQGKLQKHQAFEAEVQANSGAIVKLDETGNQMINEGHFASETIRTRLQELHRLWELLLEKMREKGVKLLQAQKLVQFLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQFAGKLIQEQHPEEELIKSKQDEVNASWQRLKGLAQQRQGKLFGAAEVQRFNRDVDETISWIKEKGQLMASDDFGRDLASVQALLRKHEGLERDLAAFHHKVKALCAEADRLQQSHPINASQIQVKREELIANWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFRSADESGQALLAAGHYASDEVKEKLTILSDERSALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMDDVATRRDALLSRRNALHERAMKRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYASDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTSVQNLQKKHALLEADVAAHQDPIDGITIQARQFQDAGHFDADNIKKKQEALVARYEALKDPMVARKQKLADSLRLQQLFRDIEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKIKLNELNQKWDSLKAKASQRRQDLEDSLQAQQYFADANEAQSWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTLITKEVGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTNEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVANDLESEGLMAEEVQAVEHQEVYGMMPRDETDSKTVSPWKSARMMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSADEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRNDEGFERDLAALGDKVNSLGETAQRLIQSHPELAEDLQEKCTELNQAWSSLGKRADQRKEKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLARGHYASPEIKEKLDILDQERTDLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAVLQSFADQLIAADHYAKGVIANRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIEMGNPLIERGACAGSEDAVKARLAALADQWEFLVQKSSEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRETINGRFQRIKSMAAARRAKLNESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVDHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCANGEDLIKKNNHHVENITAKMKGLKGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHIQSKAIEVRHASLMKRWNQLLANSAARKKKLLEAQEHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFESILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSERKPYVTKEELYQNLTREQADYCISHMKPYMDGKGRELPSAYDYIEFTRSLFVN", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[1772, 1869]]", "source": {"name": "Gallus gallus"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P07751", "PIR_ID": null}, "id": 6678, "aro": null, "reference": {"PMID": "12684010", "DOI": "10.1016/s0022-2836(03)00273-0", "description": "J MOL BIOL 1, 221-33 (2003)", "year": 2003}, "ca_depth": null, "mut_count": 4, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "A11V,V23L,M25V,V44I,V58L", "mutation_based": "PDB", "blosum62": 0, "neu": null, "ddg": 1.480845, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": 298.0, "acc": null, "don": null, "dtm": 17.1, "pam250": 1, "relative_bfactor": null, "ph": 2.0}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "DSC"}, "protein": {"PDB_path": null, "PDB_wild": "1AJ3", "name": "Spectrin alpha chain, non-erythrocytic 1", "sequence": "MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSSLRRQKLEDSYRFQFFQRDADELGKWIQEKLQIASDENYKDPSNLQGKLQKHQAFEAEVQANSGAIVKLDETGNQMINEGHFASETIRTRLQELHRLWELLLEKMREKGVKLLQAQKLVQFLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQFAGKLIQEQHPEEELIKSKQDEVNASWQRLKGLAQQRQGKLFGAAEVQRFNRDVDETISWIKEKGQLMASDDFGRDLASVQALLRKHEGLERDLAAFHHKVKALCAEADRLQQSHPINASQIQVKREELIANWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFRSADESGQALLAAGHYASDEVKEKLTILSDERSALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMDDVATRRDALLSRRNALHERAMKRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYASDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTSVQNLQKKHALLEADVAAHQDPIDGITIQARQFQDAGHFDADNIKKKQEALVARYEALKDPMVARKQKLADSLRLQQLFRDIEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKIKLNELNQKWDSLKAKASQRRQDLEDSLQAQQYFADANEAQSWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTLITKEVGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTNEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVANDLESEGLMAEEVQAVEHQEVYGMMPRDETDSKTVSPWKSARMMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSADEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRNDEGFERDLAALGDKVNSLGETAQRLIQSHPELAEDLQEKCTELNQAWSSLGKRADQRKEKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLARGHYASPEIKEKLDILDQERTDLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAVLQSFADQLIAADHYAKGVIANRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIEMGNPLIERGACAGSEDAVKARLAALADQWEFLVQKSSEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRETINGRFQRIKSMAAARRAKLNESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVDHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCANGEDLIKKNNHHVENITAKMKGLKGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHIQSKAIEVRHASLMKRWNQLLANSAARKKKLLEAQEHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFESILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSERKPYVTKEELYQNLTREQADYCISHMKPYMDGKGRELPSAYDYIEFTRSLFVN", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[1772, 1869]]", "source": {"name": "Gallus gallus"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P07751", "PIR_ID": null}, "id": 6679, "aro": null, "reference": {"PMID": "12684010", "DOI": "10.1016/s0022-2836(03)00273-0", "description": "J MOL BIOL 1, 221-33 (2003)", "year": 2003}, "ca_depth": null, "mut_count": 4, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "A11V,V23L,M25V,V44I,V58L", "mutation_based": "PDB", "blosum62": 0, "neu": null, "ddg": 0.8359610000000001, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": 298.0, "acc": null, "don": null, "dtm": 8.2, "pam250": 2, "relative_bfactor": null, "ph": 2.5}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "DSC"}, "protein": {"PDB_path": null, "PDB_wild": "1AJ3", "name": "Spectrin alpha chain, non-erythrocytic 1", "sequence": "MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSSLRRQKLEDSYRFQFFQRDADELGKWIQEKLQIASDENYKDPSNLQGKLQKHQAFEAEVQANSGAIVKLDETGNQMINEGHFASETIRTRLQELHRLWELLLEKMREKGVKLLQAQKLVQFLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQFAGKLIQEQHPEEELIKSKQDEVNASWQRLKGLAQQRQGKLFGAAEVQRFNRDVDETISWIKEKGQLMASDDFGRDLASVQALLRKHEGLERDLAAFHHKVKALCAEADRLQQSHPINASQIQVKREELIANWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFRSADESGQALLAAGHYASDEVKEKLTILSDERSALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMDDVATRRDALLSRRNALHERAMKRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYASDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTSVQNLQKKHALLEADVAAHQDPIDGITIQARQFQDAGHFDADNIKKKQEALVARYEALKDPMVARKQKLADSLRLQQLFRDIEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKIKLNELNQKWDSLKAKASQRRQDLEDSLQAQQYFADANEAQSWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTLITKEVGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTNEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVANDLESEGLMAEEVQAVEHQEVYGMMPRDETDSKTVSPWKSARMMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSADEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRNDEGFERDLAALGDKVNSLGETAQRLIQSHPELAEDLQEKCTELNQAWSSLGKRADQRKEKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLARGHYASPEIKEKLDILDQERTDLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAVLQSFADQLIAADHYAKGVIANRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIEMGNPLIERGACAGSEDAVKARLAALADQWEFLVQKSSEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRETINGRFQRIKSMAAARRAKLNESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVDHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCANGEDLIKKNNHHVENITAKMKGLKGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHIQSKAIEVRHASLMKRWNQLLANSAARKKKLLEAQEHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFESILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSERKPYVTKEELYQNLTREQADYCISHMKPYMDGKGRELPSAYDYIEFTRSLFVN", 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"Spectrin alpha chain, non-erythrocytic 1", "sequence": 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"name": "Riboflavin-binding protein", "sequence": "MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPISDTIIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQGLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSWQPPRARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLIGRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTHPGYDTGNGIQLPGTSGQQPSVGQQMIFEEHGFRRTTPPTTATPIRHRPRPYPPNVGEEIQIGHIPREDVDYHLYPHGPGLNPNASTGQEALSQTTISWAPFQDTSEYIISCHPVGTDEEPLQFRVPGTSTSATLTGLTRGATYNVIVEALKDQQRHKVREEVVTVGNSVNEGLNQPTDDSCFDPYTVSHYAVGDEWERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGGEPSPEGTTGQSYNQYSQRYHQRTNTNVNCPIECFMPLDVQADREDSRE", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[1173, 1540]]", "source": {"name": "Gallus gallus"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P02751", "PIR_ID": null}, "id": 8307, "aro": null, "reference": {"PMID": "17065159", "DOI": "10.1093/protein/gzl041", "description": "PROTEIN ENG DES SEL 12, 537-45 (2006)", "year": 2006}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "R1371I,D1373I,", "mutation_based": "PDB", "blosum62": 3, "neu": null, "ddg": 4.55, "method": {"name": "GdnHCl"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": 298.15, "acc": null, "don": null, "dtm": null, "pam250": 7, "relative_bfactor": null, "ph": 7.0}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "Fluorescence"}, "protein": {"PDB_path": null, "PDB_wild": "1FNF", "name": "Riboflavin-binding protein", "sequence": "MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPISDTIIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQGLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSWQPPRARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLIGRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTHPGYDTGNGIQLPGTSGQQPSVGQQMIFEEHGFRRTTPPTTATPIRHRPRPYPPNVGEEIQIGHIPREDVDYHLYPHGPGLNPNASTGQEALSQTTISWAPFQDTSEYIISCHPVGTDEEPLQFRVPGTSTSATLTGLTRGATYNVIVEALKDQQRHKVREEVVTVGNSVNEGLNQPTDDSCFDPYTVSHYAVGDEWERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGGEPSPEGTTGQSYNQYSQRYHQRTNTNVNCPIECFMPLDVQADREDSRE", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[1173, 1540]]", "source": {"name": "Gallus gallus"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P02751", "PIR_ID": null}, "id": 8308, "aro": null, "reference": {"PMID": "17065159", "DOI": "10.1093/protein/gzl041", "description": "PROTEIN ENG DES SEL 12, 537-45 (2006)", "year": 2006}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "A1340C,L1408P,V1442C", "mutation_based": "PDB", "blosum62": null, "neu": null, "ddg": 0.54, "method": {"name": "GdnHCl"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": 298.15, "acc": null, "don": null, "dtm": null, "pam250": null, "relative_bfactor": null, "ph": 7.0}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "NMR"}, "protein": {"PDB_path": null, "PDB_wild": "1BRF", "name": "Rubredoxin", "sequence": "MAKWVCKICGYIYDEDAGDPDNGISPGTKFEELPDDWVCPICGAPKSEFEKLED", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[2, 54]]", "source": {"name": "Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P24297", "PIR_ID": null}, "id": 8317, "aro": null, "reference": {"PMID": "17118523", "DOI": "10.1016/j.bpc.2006.10.013", "description": "BIOPHYS CHEM 2-3, 483-9 (2007)", "year": 2007}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "Y4W,V24I,I33L", "mutation_based": "PDB and Uniprot", "blosum62": -1, "neu": null, "ddg": null, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": 380.15, "acc": null, "don": null, "dtm": 6.7, "pam250": 1, "relative_bfactor": null, "ph": 9.08}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "NMR"}, "protein": {"PDB_path": null, "PDB_wild": "1BRF", "name": "Rubredoxin", "sequence": "MAKWVCKICGYIYDEDAGDPDNGISPGTKFEELPDDWVCPICGAPKSEFEKLED", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[2, 54]]", "source": {"name": "Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P24297", "PIR_ID": null}, "id": 8320, "aro": null, "reference": {"PMID": "17118523", "DOI": "10.1016/j.bpc.2006.10.013", "description": "BIOPHYS CHEM 2-3, 483-9 (2007)", "year": 2007}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "A1K,I23V,L32I", "mutation_based": "unsigned", "blosum62": 2, "neu": null, "ddg": null, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": 411.95, "acc": null, "don": null, "dtm": -6.1, "pam250": 0, "relative_bfactor": null, "ph": 9.08}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "NMR"}, "protein": {"PDB_path": null, "PDB_wild": "1BRF", "name": "Rubredoxin", "sequence": "MAKWVCKICGYIYDEDAGDPDNGISPGTKFEELPDDWVCPICGAPKSEFEKLED", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[2, 54]]", "source": {"name": "Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P24297", "PIR_ID": null}, "id": 8321, "aro": null, "reference": {"PMID": "17118523", "DOI": "10.1016/j.bpc.2006.10.013", "description": "BIOPHYS CHEM 2-3, 483-9 (2007)", "year": 2007}, "ca_depth": null, "mut_count": 3, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "A1K,W3Y,I23V,L32I", "mutation_based": "unsigned", "blosum62": 1, "neu": null, "ddg": null, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": 411.95, "acc": null, "don": null, "dtm": -10.0, "pam250": 2, "relative_bfactor": null, "ph": 9.08}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "CD"}, "protein": {"PDB_path": null, "PDB_wild": "1CSP", "name": "Cold shock protein CspB", "sequence": "MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEGQAVSFEIVEGNRGPQAANVTKEA", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[1, 67]]", "source": {"name": "Bacillus subtilis (strain 168)"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P32081", "PIR_ID": null}, "id": 8571, "aro": null, "reference": {"PMID": "17188709", "DOI": "10.1016/j.jmb.2006.11.061", "description": "J MOL BIOL 3, 842-56 (2007)", "year": 2007}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", 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"MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFPRKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRSESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQHQA", "variant_pos": "[68, 90, 116, 227, 327, 338, 358]", "length": null, "PDBs_template": null, "regions": "[[40, 358]]", "source": {"name": "Meleagris gallopavo"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P07700", "PIR_ID": null}, "id": 8847, "aro": null, "reference": {"PMID": "18192400", "DOI": "10.1073/pnas.0711253105", "description": "PROC NATL ACAD SCI U S A 3, 877-82 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 3, "neg": null, "pdb_mutant": null, "sul": null, 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"MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFPRKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRSESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQHQA", "variant_pos": "[68, 90, 116, 227, 327, 338, 358]", "length": null, "PDBs_template": null, "regions": "[[40, 358]]", "source": {"name": "Meleagris gallopavo"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P07700", "PIR_ID": null}, "id": 8848, "aro": null, "reference": {"PMID": "18192400", "DOI": "10.1073/pnas.0711253105", "description": "PROC NATL ACAD SCI U S A 3, 877-82 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 3, "neg": null, "pdb_mutant": null, "sul": null, 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"MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFPRKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRSESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQHQA", "variant_pos": "[68, 90, 116, 227, 327, 338, 358]", "length": null, "PDBs_template": null, "regions": "[[40, 358]]", "source": {"name": "Meleagris gallopavo"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P07700", "PIR_ID": null}, "id": 8849, "aro": null, "reference": {"PMID": "18192400", "DOI": "10.1073/pnas.0711253105", "description": "PROC NATL ACAD SCI U S A 3, 877-82 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 3, "neg": null, "pdb_mutant": null, "sul": null, 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"MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFPRKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRSESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQHQA", "variant_pos": "[68, 90, 116, 227, 327, 338, 358]", "length": null, "PDBs_template": null, "regions": "[[40, 358]]", "source": {"name": "Meleagris gallopavo"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P07700", "PIR_ID": null}, "id": 8850, "aro": null, "reference": {"PMID": "18192400", "DOI": "10.1073/pnas.0711253105", "description": "PROC NATL ACAD SCI U S A 3, 877-82 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 4, "neg": null, "pdb_mutant": null, "sul": null, 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"MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFPRKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRSESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQHQA", "variant_pos": "[68, 90, 116, 227, 327, 338, 358]", "length": null, "PDBs_template": null, "regions": "[[40, 358]]", "source": {"name": "Meleagris gallopavo"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P07700", "PIR_ID": null}, "id": 8851, "aro": null, "reference": {"PMID": "18192400", "DOI": "10.1073/pnas.0711253105", "description": "PROC NATL ACAD SCI U S A 3, 877-82 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 3, "neg": null, "pdb_mutant": null, "sul": null, 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"MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFPRKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRSESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQHQA", "variant_pos": "[68, 90, 116, 227, 327, 338, 358]", "length": null, "PDBs_template": null, "regions": "[[40, 358]]", "source": {"name": "Meleagris gallopavo"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P07700", "PIR_ID": null}, "id": 8852, "aro": null, "reference": {"PMID": "18192400", "DOI": "10.1073/pnas.0711253105", "description": "PROC NATL ACAD SCI U S A 3, 877-82 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, 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"MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFPRKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRSESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQHQA", "variant_pos": "[68, 90, 116, 227, 327, 338, 358]", "length": null, "PDBs_template": null, "regions": "[[40, 358]]", "source": {"name": "Meleagris gallopavo"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P07700", "PIR_ID": null}, "id": 8853, "aro": null, "reference": {"PMID": "18192400", "DOI": "10.1073/pnas.0711253105", "description": "PROC NATL ACAD SCI U S A 3, 877-82 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, 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"MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFPRKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRSESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQHQA", "variant_pos": "[68, 90, 116, 227, 327, 338, 358]", "length": null, "PDBs_template": null, "regions": "[[40, 358]]", "source": {"name": "Meleagris gallopavo"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P07700", "PIR_ID": null}, "id": 8857, "aro": null, "reference": {"PMID": "18192400", "DOI": "10.1073/pnas.0711253105", "description": "PROC NATL ACAD SCI U S A 3, 877-82 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, 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"MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFPRKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRSESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQHQA", "variant_pos": "[68, 90, 116, 227, 327, 338, 358]", "length": null, "PDBs_template": null, "regions": "[[40, 358]]", "source": {"name": "Meleagris gallopavo"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P07700", "PIR_ID": null}, "id": 8859, "aro": null, "reference": {"PMID": "18192400", "DOI": "10.1073/pnas.0711253105", "description": "PROC NATL ACAD SCI U S A 3, 877-82 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 4, "neg": null, "pdb_mutant": null, "sul": null, 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"MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFPRKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRSESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQHQA", "variant_pos": "[68, 90, 116, 227, 327, 338, 358]", "length": null, "PDBs_template": null, "regions": "[[40, 358]]", "source": {"name": "Meleagris gallopavo"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P07700", "PIR_ID": null}, "id": 8860, "aro": null, "reference": {"PMID": "18192400", "DOI": "10.1073/pnas.0711253105", "description": "PROC NATL ACAD SCI U S A 3, 877-82 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 5, "neg": null, "pdb_mutant": null, "sul": null, 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"MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFPRKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRSESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQHQA", "variant_pos": "[68, 90, 116, 227, 327, 338, 358]", "length": null, "PDBs_template": null, "regions": "[[40, 358]]", "source": {"name": "Meleagris gallopavo"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P07700", "PIR_ID": null}, "id": 8861, "aro": null, "reference": {"PMID": "18192400", "DOI": "10.1073/pnas.0711253105", "description": "PROC NATL ACAD SCI U S A 3, 877-82 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 4, "neg": null, "pdb_mutant": null, "sul": null, 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"MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFPRKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRSESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQHQA", "variant_pos": "[68, 90, 116, 227, 327, 338, 358]", "length": null, "PDBs_template": null, "regions": "[[40, 358]]", "source": {"name": "Meleagris gallopavo"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P07700", "PIR_ID": null}, "id": 8862, "aro": null, "reference": {"PMID": "18192400", "DOI": "10.1073/pnas.0711253105", "description": "PROC NATL ACAD SCI U S A 3, 877-82 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 5, "neg": null, "pdb_mutant": null, "sul": null, 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"MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFPRKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRSESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQHQA", "variant_pos": "[68, 90, 116, 227, 327, 338, 358]", "length": null, "PDBs_template": null, "regions": "[[40, 358]]", "source": {"name": "Meleagris gallopavo"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P07700", "PIR_ID": null}, "id": 8863, "aro": null, "reference": {"PMID": "18192400", "DOI": "10.1073/pnas.0711253105", "description": "PROC NATL ACAD SCI U S A 3, 877-82 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 5, "neg": null, "pdb_mutant": null, "sul": null, 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"MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFPRKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRSESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQHQA", "variant_pos": "[68, 90, 116, 227, 327, 338, 358]", "length": null, "PDBs_template": null, "regions": "[[40, 358]]", "source": {"name": "Meleagris gallopavo"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P07700", "PIR_ID": null}, "id": 8864, "aro": null, "reference": {"PMID": "18192400", "DOI": "10.1073/pnas.0711253105", "description": "PROC NATL ACAD SCI U S A 3, 877-82 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 5, "neg": null, "pdb_mutant": null, "sul": null, 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"MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFPRKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRSESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQHQA", "variant_pos": "[68, 90, 116, 227, 327, 338, 358]", "length": null, "PDBs_template": null, "regions": "[[40, 358]]", "source": {"name": "Meleagris gallopavo"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P07700", "PIR_ID": null}, "id": 8865, "aro": null, "reference": {"PMID": "18192400", "DOI": "10.1073/pnas.0711253105", "description": "PROC NATL ACAD SCI U S A 3, 877-82 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 4, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "R68S,M90V,Y227A,F327A,A334L", "mutation_based": "unsigned", "blosum62": 0, "neu": null, "ddg": null, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "unsigned", "res_depth": null, "temperature": 304.85, "acc": null, "don": null, "dtm": 15.7, "pam250": -2, "relative_bfactor": null, "ph": 8.0}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "Fluorescence"}, "protein": {"PDB_path": null, "PDB_wild": "2AFG", "name": "Fibroblast growth factor 1", "sequence": "MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[25, 153]]", "source": {"name": "Homo sapiens"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P05230", "PIR_ID": null}, "id": 8872, "aro": null, "reference": {"PMID": "18308335", "DOI": "10.1016/j.jmb.2008.01.055", "description": "J MOL BIOL 4, 1251-64 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "K12V, P134V, C117V", "mutation_based": "PDB", "blosum62": -1, "neu": null, "ddg": 2.149614, "method": {"name": "GdnHCl"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": 298.15, "acc": null, "don": null, "dtm": null, "pam250": 1, "relative_bfactor": null, "ph": 6.6}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "Activity"}, "protein": {"PDB_path": null, "PDB_wild": "4UHR", "name": "Adenosine receptor A2a", "sequence": "MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS", "variant_pos": "[48, 54, 65, 89, 154, 318, 319]", "length": null, "PDBs_template": null, "regions": "[[6, 319]]", "source": {"name": "Homo sapiens"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P29274", "PIR_ID": null}, "id": 8954, "aro": null, "reference": {"PMID": "18664584", "DOI": "10.1073/pnas.0804396105", "description": "PROC NATL ACAD SCI U S A 31, 10744-9 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "A184L,R199A,L272A", "mutation_based": "unsigned", "blosum62": 1, "neu": null, "ddg": null, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": 294.15, "acc": null, "don": null, "dtm": 5.0, "pam250": 1, "relative_bfactor": null, "ph": 7.4}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "Activity"}, "protein": {"PDB_path": null, "PDB_wild": "4UHR", "name": "Adenosine receptor A2a", "sequence": "MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS", "variant_pos": "[48, 54, 65, 89, 154, 318, 319]", "length": null, "PDBs_template": null, "regions": "[[6, 319]]", "source": {"name": "Homo sapiens"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P29274", "PIR_ID": null}, "id": 8955, "aro": null, "reference": {"PMID": "18664584", "DOI": "10.1073/pnas.0804396105", "description": "PROC NATL ACAD SCI U S A 31, 10744-9 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 4, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "A184L,R199A,L272A,F79A,L208A", "mutation_based": "unsigned", "blosum62": 1, "neu": null, "ddg": null, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": 294.15, "acc": null, "don": null, "dtm": 1.0, "pam250": 1, "relative_bfactor": null, "ph": 7.4}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "Activity"}, "protein": {"PDB_path": null, "PDB_wild": "4UHR", "name": "Adenosine receptor A2a", "sequence": "MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS", "variant_pos": "[48, 54, 65, 89, 154, 318, 319]", "length": null, "PDBs_template": null, "regions": "[[6, 319]]", "source": {"name": "Homo sapiens"}, "num_struc_mut": 7, "swissprot": null, "FASTA_path": null, "uniprot": "P29274", "PIR_ID": null}, "id": 8956, "aro": null, "reference": {"PMID": "18664584", "DOI": "10.1073/pnas.0804396105", "description": "PROC NATL ACAD SCI U S A 31, 10744-9 (2008)", "year": 2008}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "A184L,R199A,L272A", "mutation_based": 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"MVPRRPASLEVTVACIWLLTVILGFCVSFNVDVKNSMSFSGPVEDMFGYTVQQYENEEGKWVLIGSPLVGQPKARTGDVYKCPVGRERAMPCVKLDLPVNTSIPNVTEIKENMTFGSTLVTNPNGGFLACGPLYAYRCGHLHYTTGICSDVSPTFQVVNSFAPVQECSTQLDIVIVLDGSNSIYPWESVIAFLNDLLKRMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLVAANKIGRQGGLQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNYRLKQVIQDCEDENIQRFSIAILGHYNRGNLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKALGERIFALEATADQSAASFEMEMSQTGFSAHYSQDWVMLGAVGAYDWNGTVVMQKANQMVIPHNTTFQTEPAKMNEPLASYLGYTVNSATIPGDVLYIAGQPRYNHTGQVVIYKMEDGNINILQTLGGEQIGSYFGSVLTTIDIDKDSYTDLLLVGAPMYMGTEKEEQGKVYVYAVNQTRFEYQMSLEPIRQTCCSSLKDNSCTKENKNEPCGARFGTAIAAVKDLNVDGFNDVVIGAPLEDDHAGAVYIYHGSGKTIREAYAQRIPSGGDGKTLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAALFWARDVAVVKVTMNFEPNKVNIQKKNCRVEGKETVCINATMCFHVKLKSKEDSIYEADLQYRVTLDSLRQISRSFFSGTQERKIQRNITVRESECIRHSFYMLDKHDFQDSVRVTLDFNLTDPENGPVLDDALPNSVHEHIPFAKDCGNKERCISDLTLNVSTTEKSLLIVKSQHDKFNVSLTVKNKGDSAYNTRTVVQHSPNLIFSGIEEIQKDSCESNQNITCRVGYPFLRAGETVTFKIIFQFNTSHLSENAIIHLSATSDSEEPLESLNDNEVNISIPVKYEVGLQFYSSASEHHISVAANETIPEFINSTEDIGNEINVFYTIRKRGHFPMPELQLSISFPNLTADGYPVLYPIGWSSSDNVNCRPRSLEDPFGINSGKKMTISKSEVLKRGTIQDCSSTCGVATITCSLLPSDLSQVNVSLLLWKPTFIRAHFSSLNLTLRGELKSENSSLTLSSSNRKRELAIQISKDGLPGRVPLWVILLSAFAGLLLLMLLILALWKIGFFKRPLKKKMEK", 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"1MHP", "name": "Integrin alpha-1", "sequence": 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"1MHP", "name": "Integrin alpha-1", "sequence": "MVPRRPASLEVTVACIWLLTVILGFCVSFNVDVKNSMSFSGPVEDMFGYTVQQYENEEGKWVLIGSPLVGQPKARTGDVYKCPVGRERAMPCVKLDLPVNTSIPNVTEIKENMTFGSTLVTNPNGGFLACGPLYAYRCGHLHYTTGICSDVSPTFQVVNSFAPVQECSTQLDIVIVLDGSNSIYPWESVIAFLNDLLKRMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLVAANKIGRQGGLQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNYRLKQVIQDCEDENIQRFSIAILGHYNRGNLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKALGERIFALEATADQSAASFEMEMSQTGFSAHYSQDWVMLGAVGAYDWNGTVVMQKANQMVIPHNTTFQTEPAKMNEPLASYLGYTVNSATIPGDVLYIAGQPRYNHTGQVVIYKMEDGNINILQTLGGEQIGSYFGSVLTTIDIDKDSYTDLLLVGAPMYMGTEKEEQGKVYVYAVNQTRFEYQMSLEPIRQTCCSSLKDNSCTKENKNEPCGARFGTAIAAVKDLNVDGFNDVVIGAPLEDDHAGAVYIYHGSGKTIREAYAQRIPSGGDGKTLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAALFWARDVAVVKVTMNFEPNKVNIQKKNCRVEGKETVCINATMCFHVKLKSKEDSIYEADLQYRVTLDSLRQISRSFFSGTQERKIQRNITVRESECIRHSFYMLDKHDFQDSVRVTLDFNLTDPENGPVLDDALPNSVHEHIPFAKDCGNKERCISDLTLNVSTTEKSLLIVKSQHDKFNVSLTVKNKGDSAYNTRTVVQHSPNLIFSGIEEIQKDSCESNQNITCRVGYPFLRAGETVTFKIIFQFNTSHLSENAIIHLSATSDSEEPLESLNDNEVNISIPVKYEVGLQFYSSASEHHISVAANETIPEFINSTEDIGNEINVFYTIRKRGHFPMPELQLSISFPNLTADGYPVLYPIGWSSSDNVNCRPRSLEDPFGINSGKKMTISKSEVLKRGTIQDCSSTCGVATITCSLLPSDLSQVNVSLLLWKPTFIRAHFSSLNLTLRGELKSENSSLTLSSSNRKRELAIQISKDGLPGRVPLWVILLSAFAGLLLLMLLILALWKIGFFKRPLKKKMEK", 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"2BRD", "name": "Bacteriorhodopsin", "sequence": "MLELLPTAVEGVSQAQITGRPEWIWLALGTALMGLGTLYFLVKGMGVSDPDAKKFYAITTLVPAIAFTMYLSMLLGYGLTMVPFGGEQNPIYWARYADWLFTTPLLLLDLALLVDADQGTILALVGADGIMIGTGLVGALTKVYSYRFVWWAISTAAMLYILYVLFFGFTSKAESMRPEVASTFKVLRNVTVVLWSAYPVVWLIGSEGAGIVPLNIETLLFMVLDVSAKVGFGLILLRSRAIFGEAEAPEPSAGDGAAATSD", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[20, 241]]", "source": {"name": "Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P02945", "PIR_ID": null}, "id": 10349, "aro": null, "reference": {"PMID": "24341610", "DOI": "10.1111/febs.12694", "description": "FEBS J 4, 1181-95 (2014)", "year": 2014}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "E22Q, E207Q, E217Q", "mutation_based": "PDB and Uniprot", "blosum62": 3, "neu": null, "ddg": null, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": null, "acc": null, "don": null, "dtm": -7.2, "pam250": 7, "relative_bfactor": null, "ph": 3.5}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "DSC"}, "protein": {"PDB_path": null, "PDB_wild": "2BRD", "name": "Bacteriorhodopsin", "sequence": "MLELLPTAVEGVSQAQITGRPEWIWLALGTALMGLGTLYFLVKGMGVSDPDAKKFYAITTLVPAIAFTMYLSMLLGYGLTMVPFGGEQNPIYWARYADWLFTTPLLLLDLALLVDADQGTILALVGADGIMIGTGLVGALTKVYSYRFVWWAISTAAMLYILYVLFFGFTSKAESMRPEVASTFKVLRNVTVVLWSAYPVVWLIGSEGAGIVPLNIETLLFMVLDVSAKVGFGLILLRSRAIFGEAEAPEPSAGDGAAATSD", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[20, 241]]", "source": {"name": "Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P02945", "PIR_ID": null}, "id": 10350, "aro": null, "reference": {"PMID": "24341610", "DOI": "10.1111/febs.12694", "description": "FEBS J 4, 1181-95 (2014)", "year": 2014}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "E22Q, E207Q, E217Q", "mutation_based": "PDB and Uniprot", "blosum62": 2, "neu": null, "ddg": null, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": null, "acc": null, "don": null, "dtm": -11.9, "pam250": 2, "relative_bfactor": null, "ph": 9.0}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "DSC"}, "protein": {"PDB_path": null, "PDB_wild": "1TEN", "name": "Tenascin", "sequence": "MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTEALPLLENLTISDINPYGFTVSWMASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQGHQTKPLRAEIVTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA", 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"name": "Tenascin", "sequence": "MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTEALPLLENLTISDINPYGFTVSWMASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQGHQTKPLRAEIVTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[802, 891]]", "source": {"name": "Homo sapiens"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P24821", "PIR_ID": null}, "id": 10630, "aro": null, "reference": {"PMID": "24996411", "DOI": "10.1093/protein/gzu024", "description": "PROTEIN ENG DES SEL 10, 411-8 (2014)", "year": 2014}, "ca_depth": null, "mut_count": 3, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "E887I, T890K, D850K, I833F", "mutation_based": "PDB and Uniprot", "blosum62": 0, "neu": null, "ddg": null, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": null, "acc": null, "don": null, "dtm": 23.9, "pam250": 0, "relative_bfactor": null, "ph": 7.4}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "CD"}, "protein": {"PDB_path": null, "PDB_wild": "1OPG", "name": "OPG2_FAB_VL", "sequence": "", "variant_pos": "[0]", "length": null, "PDBs_template": null, "regions": "[[]]", "source": {"name": "Human"}, "num_struc_mut": 1, "swissprot": null, "FASTA_path": null, "uniprot": "-", "PIR_ID": null}, "id": 10636, "aro": null, "reference": {"PMID": "25096580", "DOI": "10.1074/jbc.M114.582247", "description": "J BIOL CHEM 39, 26829-46 (2014)", "year": 2014}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "E2I, G100A, S102T", "mutation_based": "unsigned", "blosum62": 1, "neu": null, "ddg": -2.8183830000000003, "method": {"name": "GdnHCl"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "unsigned", "res_depth": null, "temperature": 298.15, "acc": null, "don": null, "dtm": 13.2, "pam250": 1, "relative_bfactor": null, "ph": 7.4}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "Fluorescence"}, "protein": {"PDB_path": null, "PDB_wild": "2AFG", "name": "Fibroblast growth factor 1", "sequence": "MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[25, 153]]", "source": {"name": "Homo sapiens"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P05230", "PIR_ID": null}, "id": 10667, "aro": null, "reference": {"PMID": "25312596", "DOI": "10.1007/s10858-014-9866-7", "description": "J BIOMOL NMR 2-3, 169-87 (2014)", "year": 2015}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "K27V, C132V, P149V", "mutation_based": "Uniprot", "blosum62": -2, "neu": null, "ddg": 3.42, "method": {"name": "GdnHCl"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": 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"MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEALRAALQHCPKKKL", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[4, 391]]", "source": {"name": "Homo sapiens"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P21549", "PIR_ID": null}, "id": 10708, "aro": null, "reference": {"PMID": "25461797", "DOI": "10.1016/j.bbapap.2014.10.010", "description": "BIOCHIM BIOPHYS ACTA 12, 2355-65 (2014)", "year": 2014}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "P11L, I340M, G170R", "mutation_based": "PDB and Uniprot", "blosum62": -3, "neu": null, "ddg": null, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": null, "acc": null, "don": null, "dtm": 5.5, "pam250": -1, "relative_bfactor": null, "ph": 7.4}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "DSC"}, "protein": {"PDB_path": null, "PDB_wild": "1H0C", "name": "Serine--pyruvate aminotransferase", "sequence": "MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEALRAALQHCPKKKL", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[4, 391]]", "source": {"name": "Homo sapiens"}, "num_struc_mut": 0, 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"MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEALRAALQHCPKKKL", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[4, 391]]", "source": {"name": "Homo sapiens"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P21549", "PIR_ID": null}, "id": 10710, "aro": null, "reference": {"PMID": "25461797", "DOI": "10.1016/j.bbapap.2014.10.010", "description": "BIOCHIM BIOPHYS ACTA 12, 2355-65 (2014)", "year": 2014}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "P11L, I340M, I244T", "mutation_based": "PDB and Uniprot", "blosum62": 0, "neu": null, "ddg": null, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": null, "acc": null, "don": null, "dtm": 5.8, "pam250": 1, "relative_bfactor": null, "ph": 7.4}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "DSC"}, "protein": {"PDB_path": null, "PDB_wild": "1H0C", "name": "Serine--pyruvate aminotransferase", "sequence": "MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEALRAALQHCPKKKL", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[4, 391]]", "source": {"name": "Homo sapiens"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P21549", "PIR_ID": null}, "id": 10711, "aro": null, "reference": {"PMID": "25461797", "DOI": "10.1016/j.bbapap.2014.10.010", "description": "BIOCHIM BIOPHYS ACTA 12, 2355-65 (2014)", "year": 2014}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "P11L, I340M, A295T", "mutation_based": "PDB and Uniprot", "blosum62": 1, "neu": null, "ddg": null, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": null, "acc": null, "don": null, "dtm": 7.5, "pam250": 1, "relative_bfactor": null, "ph": 7.4}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "DSC"}, "protein": {"PDB_path": null, "PDB_wild": "1H0C", "name": "Serine--pyruvate aminotransferase", "sequence": 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{"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": 313.15, "acc": null, "don": null, "dtm": 10.6, "pam250": -2, "relative_bfactor": null, "ph": 8.0}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "DSF"}, "protein": {"PDB_path": null, "PDB_wild": "2FX5", "name": "Lipase", "sequence": "MLDLKLGGLAAACLLVCSTALAAPLPDTPGAPFPAVANFDRSGPYATSNQSEGPSCRIYRPSNLGQGGVRHPVILWGNGTGTGPSTYAGLLSHWASHGFVVAAAETSNAGTGREMLACLDYLVRENDNPYGTYAGKLNTGRVGTSGHSQGGGGSIMAGQDTRVRTTAPIQPYTIGLGHDSASQRRQQGPMFLMSGGGDTIAIPYLNAQPVYLRANVPVFWGERRYVSHFEPVGDGGAYRGPSTAWFRFQLMDDQSARGTFYGTLCSLCSSLLWSVERRGF", "variant_pos": "[46, 47, 49, 62, 63, 82, 128, 134, 174, 202, 212, 234, 255, 258, 263, 264, 269, 280]", "length": null, "PDBs_template": null, "regions": "[[23, 280]]", "source": {"name": "Pseudomonas mendocina"}, "num_struc_mut": 18, "swissprot": null, "FASTA_path": null, "uniprot": "A4Y035", "PIR_ID": null}, "id": 11711, "aro": null, "reference": {"PMID": "29101200", "DOI": "10.1128/AEM.02129-17", "description": "APPL ENVIRON MICROBIOL 2,  (2018)", "year": 2018}, "ca_depth": null, "mut_count": 4, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "T112K, T116I, E324I, V283C, D332C", "mutation_based": "unsigned", "blosum62": 0, "neu": null, "ddg": null, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": 313.15, "acc": null, "don": null, "dtm": 13.6, "pam250": 0, "relative_bfactor": null, "ph": 8.0}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "CD"}, "protein": {"PDB_path": null, "PDB_wild": "1XZO", "name": "SCO1 protein homolog", "sequence": "MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKNVSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDKPKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYLVGPDGKVLKDYNGVENTPYDDIISDVKSASTLK", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[22, 193]]", "source": {"name": "Bacillus subtilis (strain 168)"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P54178", "PIR_ID": null}, "id": 11720, "aro": null, "reference": {"PMID": "29131589", "DOI": "10.1021/acs.biochem.7b00833", "description": "BIOCHEMISTRY 48, 6355-6367 (2017)", "year": 2017}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "W36F, W101F, F42W", "mutation_based": "PDB", "blosum62": -1, "neu": null, "ddg": null, "method": {"name": "Urea"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "A", "res_depth": null, "temperature": 298.15, "acc": null, "don": null, "dtm": -18.0, "pam250": -2, "relative_bfactor": null, "ph": 7.0}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "CD, DSF"}, "protein": {"PDB_path": null, "PDB_wild": "1OIN", "name": "Beta-glucosidase A", "sequence": "MNVKKFPEGFLWGVATASYQIEGSPLADGAGMSIWHTFSHTPGNVKNGDTGDVACDHYNRWKEDIEIIEKLGVKAYRFSISWPRILPEGTGRVNQKGLDFYNRIIDTLLEKGITPFVTIYHWDLPFALQLKGGWANREIADWFAEYSRVLFENFGDRVKNWITLNEPWVVAIVGHLYGVHAPGMRDIYVAFRAVHNLLRAHARAVKVFRETVKDGKIGIVFNNGYFEPASEKEEDIRAVRFMHQFNNYPLFLNPIYRGDYPELVLEFAREYLPENYKDDMSEIQEKIDFVGLNYYSGHLVKFDPDAPAKVSFVERDLPKTAMGWEIVPEGIYWILKKVKEEYNPPEVYITENGAAFDDVVSEDGRVHDQNRIDYLKAHIGQAWKAIQEGVPLKGYFVWSLLDNFEWAEGYSKRFGIVYVDYSTQKRIVKDSGYWYSNVVKNNGLED", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[2, 445]]", "source": {"name": "Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "Q08638", "PIR_ID": null}, "id": 11747, "aro": null, "reference": {"PMID": "29338043", "DOI": "10.1371/journal.pone.0191282", "description": "PLOS ONE 1, E0191282 (2018)", "year": 2018}, "ca_depth": null, "mut_count": 3, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "W12A, H195A, I217A, F404A", "mutation_based": "unsigned", "blosum62": 3, "neu": null, "ddg": null, "method": {"name": "GdnHCL"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "unsigned", "res_depth": null, "temperature": 363.15, "acc": null, "don": null, "dtm": -8.0, "pam250": 4, "relative_bfactor": null, "ph": null}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "DSF"}, "protein": {"PDB_path": null, "PDB_wild": "4NC0", "name": "A26.8 VHH antibody", "sequence": "", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[1, 248]]", "source": {"name": "Lama glama"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "D5RWT1", "PIR_ID": null}, "id": 11756, "aro": null, "reference": {"PMID": "29396522", "DOI": "10.1038/s41598-018-20599-4", "description": "SCI REP 1, 2260 (2018)", "year": 2018}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "T56R, Q101K, T103R", "mutation_based": "unsigned", "blosum62": -1, "neu": null, "ddg": 1.31, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "B", "res_depth": null, "temperature": 303.15, "acc": null, "don": null, "dtm": 3.4, "pam250": -1, "relative_bfactor": null, "ph": 7.4}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "DSF"}, "protein": {"PDB_path": null, "PDB_wild": "4NC0", "name": "A26.8 VHH antibody", "sequence": "", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[1, 248]]", "source": {"name": "Lama glama"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "D5RWT1", "PIR_ID": null}, "id": 11758, "aro": null, "reference": {"PMID": "29396522", "DOI": "10.1038/s41598-018-20599-4", "description": "SCI REP 1, 2260 (2018)", "year": 2018}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "T56R, Q101K, T103M", "mutation_based": "unsigned", "blosum62": 1, "neu": null, "ddg": 1.1, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "B", "res_depth": null, "temperature": 303.15, "acc": null, "don": null, "dtm": 2.7, "pam250": 1, "relative_bfactor": null, "ph": 7.4}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "DSF"}, "protein": {"PDB_path": null, "PDB_wild": "4NC0", "name": "A26.8 VHH antibody", "sequence": "", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[1, 248]]", "source": {"name": "Lama glama"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "D5RWT1", "PIR_ID": null}, "id": 11759, "aro": null, "reference": {"PMID": "29396522", "DOI": "10.1038/s41598-018-20599-4", "description": "SCI REP 1, 2260 (2018)", "year": 2018}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "T56R, Q101K, T103K", "mutation_based": "unsigned", "blosum62": 1, "neu": null, "ddg": 1.03, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "B", "res_depth": null, "temperature": 303.15, "acc": null, "don": null, "dtm": 3.1, "pam250": 1, "relative_bfactor": null, "ph": 7.4}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "Fluorescence"}, "protein": {"PDB_path": null, "PDB_wild": "2PZE", "name": "Cystic fibrosis transmembrane conductance regulator", "sequence": "MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL", "variant_pos": "[386, 470]", "length": null, "PDBs_template": null, "regions": "[[386, 645]]", "source": {"name": "Homo sapiens"}, "num_struc_mut": 2, "swissprot": null, "FASTA_path": null, "uniprot": "P13569", "PIR_ID": null}, "id": 11788, "aro": null, "reference": {"PMID": "29425673", "DOI": "10.1016/j.bbamem.2018.02.006", "description": "BIOCHIM BIOPHYS ACTA BIOMEMBR 5, 1193-1204 (2018)", "year": 2018}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "S492P, A534P, I539T", "mutation_based": "unsigned", "blosum62": -1, "neu": null, "ddg": null, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "unsigned", "res_depth": null, "temperature": 295.38, "acc": null, "don": null, "dtm": 2.77, "pam250": -1, "relative_bfactor": null, "ph": 7.5}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "Fluorescence"}, "protein": {"PDB_path": null, "PDB_wild": "2PZE", "name": "Cystic fibrosis transmembrane conductance regulator", "sequence": "MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL", 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{"PDB_path": null, "PDB_wild": "2PZE", "name": "Cystic fibrosis transmembrane conductance regulator", "sequence": "MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL", 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"protein": {"PDB_path": null, "PDB_wild": "2PZE", "name": "Cystic fibrosis transmembrane conductance regulator", "sequence": "MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL", 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"protein": {"PDB_path": null, "PDB_wild": "2PZE", "name": "Cystic fibrosis transmembrane conductance regulator", "sequence": "MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL", 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calorimetry"}, "protein": {"PDB_path": null, "PDB_wild": "1B0O", "name": "Beta-lactoglobulin", "sequence": "MKCLLLALALTCGAQALIVTQTMKGLDIQKVAGTWYSLAMAASDISLLDAQSAPLRVYVEELKPTPEGDLEILLQKWENGECAQKKIIAEKTKIPAVFKIDALNENKVLVLDTDYKKYLLFCMENSAEPEQSLACQCLVRTPEVDDEALEKFDKALKALPMHIRLSFNPTQLEEQCHI", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[18, 178]]", "source": {"name": "Bos taurus"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P02754", "PIR_ID": null}, "id": 11817, "aro": null, "reference": {"PMID": "29555509", "DOI": "10.1016/j.ijbiomac.2018.03.074", "description": "INT J BIOL MACROMOL , 85-96 (2018)", "year": 2018}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": "2BLG", "sul": null, "mutation_type": "Multiple", "mutation_code": "I56F, L39A, M107F", "mutation_based": "unsigned", "blosum62": 0, "neu": null, "ddg": -0.48, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "unsigned", "res_depth": null, "temperature": 298.15, "acc": null, "don": null, "dtm": -5.8, "pam250": 0, "relative_bfactor": null, "ph": 7.5}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "Isothermal titration calorimetry"}, "protein": {"PDB_path": null, "PDB_wild": "1B0O", "name": "Beta-lactoglobulin", "sequence": "MKCLLLALALTCGAQALIVTQTMKGLDIQKVAGTWYSLAMAASDISLLDAQSAPLRVYVEELKPTPEGDLEILLQKWENGECAQKKIIAEKTKIPAVFKIDALNENKVLVLDTDYKKYLLFCMENSAEPEQSLACQCLVRTPEVDDEALEKFDKALKALPMHIRLSFNPTQLEEQCHI", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[18, 178]]", "source": {"name": "Bos taurus"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P02754", "PIR_ID": null}, "id": 11819, "aro": null, "reference": {"PMID": "29555509", "DOI": "10.1016/j.ijbiomac.2018.03.074", "description": "INT J BIOL MACROMOL , 85-96 (2018)", "year": 2018}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": "2BLG", "sul": null, "mutation_type": "Multiple", "mutation_code": "F105L, L39A, M107F", "mutation_based": "unsigned", "blosum62": -2, "neu": null, "ddg": 0.0, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "unsigned", "res_depth": null, "temperature": 298.15, "acc": null, "don": null, "dtm": 10.2, "pam250": -3, "relative_bfactor": null, "ph": 7.5}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "CD"}, "protein": {"PDB_path": null, "PDB_wild": "1PMM", "name": "Glutamate decarboxylase beta", "sequence": "MDKKQVTDLRSELLDSRFGAKSISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNLATFCQTWDDENVHKLMDLSINKNWIDKEEYPQSAAIDLRCVNMVADLWHAPAPKNGQAVGTNTIGSSEACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGPVQICWHKFARYWDVELREIPMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDMHIDAASGGFLAPFVAPDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQIGTFAINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKLGPYEFICTGRPDEGIPAVCFKLKDGEDPGYTLYDLSERLRLRGWQVPAFTLGGEATDIVVMRIMCRRGFEMDFAELLLEDYKASLKYLSDHPKLQGIAQQNSFKHT", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[3, 452]]", "source": {"name": "Escherichia coli (strain K12)"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P69910", "PIR_ID": null}, "id": 11832, "aro": null, "reference": {"PMID": "29660473", "DOI": "10.1016/j.jbiotec.2018.04.009", "description": "J BIOTECHNOL , 1-9 (2018)", "year": 2018}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "Q5N, V6Y, T7V", "mutation_based": "unsigned", "blosum62": -1, "neu": null, "ddg": null, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "unsigned", "res_depth": null, "temperature": 318.15, "acc": null, "don": null, "dtm": 2.0, "pam250": -2, "relative_bfactor": null, "ph": 3.8}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "CD"}, "protein": {"PDB_path": null, "PDB_wild": "1PMM", "name": "Glutamate decarboxylase beta", "sequence": "MDKKQVTDLRSELLDSRFGAKSISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNLATFCQTWDDENVHKLMDLSINKNWIDKEEYPQSAAIDLRCVNMVADLWHAPAPKNGQAVGTNTIGSSEACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGPVQICWHKFARYWDVELREIPMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDMHIDAASGGFLAPFVAPDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQIGTFAINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKLGPYEFICTGRPDEGIPAVCFKLKDGEDPGYTLYDLSERLRLRGWQVPAFTLGGEATDIVVMRIMCRRGFEMDFAELLLEDYKASLKYLSDHPKLQGIAQQNSFKHT", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[3, 452]]", "source": {"name": "Escherichia coli (strain K12)"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P69910", "PIR_ID": null}, "id": 11833, "aro": null, "reference": {"PMID": "29660473", "DOI": "10.1016/j.jbiotec.2018.04.009", "description": "J BIOTECHNOL , 1-9 (2018)", "year": 2018}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, "mutation_type": "Multiple", "mutation_code": "Q5I, V6D, T7Q", "mutation_based": "unsigned", "blosum62": -2, "neu": null, "ddg": null, "method": {"name": "Thermal"}, "phi": null, "psi": null, "sst": null, "effect": null, "rsa": null, "mutated_chain": "unsigned", "res_depth": null, "temperature": 318.15, "acc": null, "don": null, "dtm": 8.7, "pam250": -3, "relative_bfactor": null, "ph": 3.8}, {"weight": null, "pos": null, "pdbs_template": null, "measure": {"name": "CD"}, "protein": {"PDB_path": null, "PDB_wild": "1PMM", "name": "Glutamate decarboxylase beta", "sequence": "MDKKQVTDLRSELLDSRFGAKSISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNLATFCQTWDDENVHKLMDLSINKNWIDKEEYPQSAAIDLRCVNMVADLWHAPAPKNGQAVGTNTIGSSEACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGPVQICWHKFARYWDVELREIPMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDMHIDAASGGFLAPFVAPDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQIGTFAINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKLGPYEFICTGRPDEGIPAVCFKLKDGEDPGYTLYDLSERLRLRGWQVPAFTLGGEATDIVVMRIMCRRGFEMDFAELLLEDYKASLKYLSDHPKLQGIAQQNSFKHT", "variant_pos": "[]", "length": null, "PDBs_template": null, "regions": "[[3, 452]]", "source": {"name": "Escherichia coli (strain K12)"}, "num_struc_mut": 0, "swissprot": null, "FASTA_path": null, "uniprot": "P69910", "PIR_ID": null}, "id": 11834, "aro": null, "reference": {"PMID": "29660473", "DOI": "10.1016/j.jbiotec.2018.04.009", "description": "J BIOTECHNOL , 1-9 (2018)", "year": 2018}, "ca_depth": null, "mut_count": 2, "neg": null, "pdb_mutant": null, "sul": null, 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